化粧品原料を研究し、信頼・満足される製品作りを目指します。全世界の皮膚科学の専門医や技術者に信頼・満足される製品作りを目指し1988年以来弊社は、医療機関と協力して化粧品原料の開発を行ってまいりました。化粧品原料の有効性とその蓄積されたエビデンスこそがドクター、患者様の信頼と満足につながる製品作りの原点であると考えております。弊社は、数ある化粧品原料がある中でもビタミンＣ誘導体におきましてはその特性を生かした製剤の研究に力を入れており皮膚科学の専門大学や医療機関と連携を取りその共同研究により得られた知見やデータに基づき最適な製剤作りを目指しております。弊社は、２００３年から日本皮膚科学会総会、日本形成外科学会総会等で以下のような企業セミナーを開催し、化粧品や美容に関連する科学振興を支援しています。

The cosmetics we aim for are not "natural," "botanical," "additive-free," or "the cutting edge of fashion."It is "Evidence-based cosmetic".It is our mission to stick to the scientific evidence of cosmetics.We believe that even cosmetics in very beautiful containers are meaningless unless their effects are scientifically proven.In particular, ITO continued to stick to presentations at academic conferences of dermatologists and plastic surgeons.To that end, we have endeavored to obtain a lot of cosmetic evidence.Since 2003, ITO has been continuing the activities of the following cosmetic-related academic societies, centered on the General Assembly of the Japanese Dermatological Association and the General Assembly of the Japan Society of Plastic and Reconstructive Surgery. And we will leverage the opinions of dermatologists who are rigorous experts in cosmetics development.Please try the "evidence-based cosmetics" that we have continued to develop.

화장품 원료를 연구하고 신뢰 · 만족하는 제품 만들기를 목표로합니다. 전 세계 피부과 전문의와 기술자에 신뢰 · 만족하는 제품 만들기를 목표로 1988 년부터 당사는 의료 기관과 협력하여 화장품 원료 개발을하고 왔습니다. 화장품 원료의 유효성과 그 축적 된 증거 이야말로 닥터 환자의 신뢰와 만족으로 이어질 제품 만들기의 원점이라고 생각하고 있습니다. 당사는 많은 화장품 성분이 중에서도 비타민 C 유도체에 있어서는 그 특성을 살린 제제의 연구에 주력하고 피부과 전문 대학이나 의료 기관과 연계를 가지고 그 공동 연구를 통해 얻은 지식이나 데이터에 따라 최적의 제제 만들기를 목표로하고 있습니다. 당사는 2003 년부터 일본 피부과 학회 총회 일본 성형 외과 학회 총회 등에서 다음과 같은 기업 세미나를 개최하고, 화장품이나 미용 관련 과학 진흥을 지원하고 있습니다.

我们追求的化妆品不是"天然","植物基","无添加剂"或"时尚前沿"。我们追求的化妆品是"循证化妆品"。科学证明化妆品的功效是我们的使命。我们认为，除非美容效果得到科学证明，否则将其放在非常漂亮的容器中是完全没有意义的。尤其是，ITO继续在皮肤科医生和整形外科医生的学术团体中发表演讲。因此，我们一直在努力获取大量的科学证据。自2003年以来，ITO一直活跃在以下与化妆品相关的学术团体中，以日本皮肤病学协会大会和日本整形外科学会会员大会为中心。我们将严格的皮肤科医生建议应用于化妆品开发。我们的化妆品和化妆品成分被世界各地的许多皮肤科医生所使用。应该尝试我们的"循证化妆品"。

Scheduled to be held in 2021

The 64th Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery Hands-on Seminar [Lecture Seminar Capacity: 86 people]

Thursday, April 15, 2021 Hotel Chinzanso Tokyo 7F

Moderator: Professor KAZUO KISHI, Department of Plastic Surgery, Keio University School of Medicine

Clinic Mori Ayako

Chemical peeling is one of the treatments that promotes skin regeneration using chemicals such as glycolic acid and salicylic acid, and is expected to improve various skin problems, and is widely used in medical institutions. In recent years, it has been found that the latest amphipathic vitamin C derivative GO-VC® may enhance the proliferation and differentiation of epidermal keratinocytes, and it is considered that it may have a peeling action. Therefore, this time, we prepared a preparation containing GO-VC® and glycolic acid, which is a typical peeling drug, and examined its effect on pigmentation.

化学脱皮是使用乙醇酸和水杨酸等化学物质促进皮肤再生的治疗方法之一，有望改善各种皮肤问题，并在医疗机构中广泛使用。近年来，已经发现最新的两亲性维生素C衍生物GO-VC®可以增强表皮角质形成细胞的增殖和分化，并且认为其可能具有剥离作用。因此，这次，我们制备了一种含有GO-VC®和乙醇酸（一种典型的脱皮药物）的制剂，并研究了其对色素沉着的影响。

Lecturer Takeshi Nagata, IT O Pro Vitamin Research Center

New Functions of Amphiphile Vitamin C Derivatives GO-VC®-Skin Regeneration / Peeling-Like Action-

Vitamin C (AsA) and AsA derivatives are known to be effective for skin regeneration, especially acne scars, because they promote the proliferation of dermal fibroblasts and the production of type I collagen. Similar effects have been confirmed with the latest AsA derivative, GO-VC®, and in recent years, it has been found that GO-VC® may promote the proliferation and differentiation of epidermal keratinocytes. May have a different new skin regeneration / peeling-like mechanism of action. Therefore, this time, we report on the skin regeneration / peeling-like action mechanism of GO-VC®, focusing on epidermal stem cells in addition to the above.

众所周知，维生素C（AsA）和AsA衍生物可有效促进皮肤再生，尤其是痤疮疤痕，因为它们可促进皮肤成纤维细胞的增殖和I型胶原蛋白的产生。最新的AsA衍生物GO-VC®证实了类似的作用，并且近年来发现GO-VC®可能促进表皮角质形成细胞的增殖和分化。可能具有不同的新皮肤再生/脱皮样作用机理。因此，这次，除了上述以外，我们还报告了GO-VC®的皮肤再生/类脱皮作用机制，重点是表皮干细胞。

The 120th Annual Meeting of the Japanese Dermatological Association Morning Seminar

Date / Venue June 10, 2020 Pacifico Yokohama

Chair Professor Akira Kawada, Department of Dermatology, Faculty of Medicine, Kinki University

Clinic Mori Ayako

Chemical peeling is one of the treatments that promotes skin regeneration by using chemicals such as glycolic acid and salicylic acid, and is expected to improve various skin troubles, and is widely used in medical institutions. In recent years, it has been found that the latest amphipathic vitamin C derivative GO-VC® may enhance the proliferation and differentiation of epidermal keratinocytes, and it is considered that it may have a peeling action. Therefore, this time, we prepared a preparation containing GO-VC® and glycolic acid, which is a typical peeling drug, and examined its effect on pigmentation.

化学脱皮是通过使用乙醇酸和水杨酸等化学物质促进皮肤再生的治疗方法之一，有望改善各种皮肤不适，并且在医疗机构中得到广泛使用。两亲性维生素C衍生物GO-VC®可能增强表皮角质形成细胞的增殖和分化，并被认为具有剥离作用，因此，本次我们制备了一种含有GO-VC®和乙醇酸的制剂。一种典型的脱皮药物，并检查了其对色素沉着的影响。

Lecturer Takeshi Nagata, IT O Pro Vitamin Research Center

New Functions of Amphiphile Vitamin C Derivatives GO-VC®-Skin Regeneration / Peeling-Like Action-

已知维生素C（AsA）和AsA衍生物可促进皮肤再生，尤其是痤疮疤痕，因为它们可促进皮肤成纤维细胞的增殖和I型胶原蛋白的产生，最新的AsA衍生物GO-也证实了类似的效果。 VC®，并且近年来发现GO-VC®可能促进表皮角质形成细胞的增殖和分化，可能具有不同的新的皮肤再生/脱皮样作用机理，因此，本次我们报道GO-VC®的皮肤再生/脱皮样作用机制，除了上述以外，还着重于表皮干细胞。

2020

The 63rd Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery / Academic Meeting Luncheon Seminar 20

Co-sponsored the 63rd Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery / ITO Co., Ltd.

Nagoya Congress Center 7th Venue (Building No. 4, 3rd Floor, 431, 432) April 10, 2020 (Friday) Luncheon Seminar 12: 15-13: 15

Combined effect of retinoid and ascorbic acid derivative

Moderator: Professor Kazuo Kishi, Department of Plastic Surgery, Keio University School of Medicine

Clinic Mori

Ayako Mori

Retinol is used for the treatment of wrinkles and pigmentation, but the concentration and method for efficiently exerting these effects have been unknown in cosmetics.

The ascorbic acid (AsA) derivative nanocapsule has a coating composed of GO-VC, which is a novel amphipathic AsA derivative, and a synergistic effect between GO-VC and the inclusion component can be expected. It is also possible to improve the stability and skin permeability of the inclusion component. Therefore, we report on the effects of 0.3% and 0.5% retinol-encapsulated AsA derivative nanocapsules prepared on wrinkles and pigmentation.

视黄醇用于治疗皱纹和色素沉着，但在化妆品中尚无有效发挥这些作用的浓度和方法。

抗坏血酸（AsA）衍生物纳米胶囊具有由GO-VC组成的涂层，这是一种新型的两亲性AsA衍生物，可以期待GO-VC与包含物之间的协同作用。还可以改善内含物组分的稳定性和皮肤渗透性。因此，我们报告了制备的0.3％和0.5％视黄醇封装的AsA衍生物纳米胶囊对皱纹和色素沉着的影响。

IT O Pro Vitamin Research Center Co., Ltd.

Takeshi Nagata

GO-VC is a novel amphipathic AsA derivative having excellent stability in which glycerin and octanol are bound to ascorbic acid (AsA). Numerous cell and clinical trials have been conducted, and its effects on acne vulgaris, wrinkles, pigmentation, etc. have been confirmed. In particular, it was confirmed that the whitening action mechanism has a plurality of new action mechanisms different from those of the conventional AsA derivatives. This time, we will explain in detail the surprising whitening action mechanism of GO-VC, and also introduce the AsA derivative nanocapsule raw material with data.

抗坏血酸（AsA）衍生物纳米胶囊具有由新型两亲性AsA衍生物GO-VC组成的涂层，可以期待GO-VC与包合物的协同作用，还可以提高稳定性和稳定性。因此，我们报道了制备的0.3％和0.5％视黄醇封装的AsA衍生物纳米胶囊对皱纹和色素沉着的影响。

The 119th Annual Meeting of the Japanese Dermatological Association Morning Seminar 5

"Effect of combined use of retinoid and ascorbic acid derivative"

Date / Venue June 6, 2020 (Sat) 8: 00-9: 00 Venue 8 (Kyoto International Conference Center 1F Room C-1) 130 seats

Chair Professor Akira Kawada, Department of Dermatology, Faculty of Medicine, Kinki University

Ayako Mori (Clinic Mori)

Examination of the effect of retinol-encapsulated ascorbic acid derivative nanocapsule preparation on wrinkles and pigmentation

Retinol is known to be converted to retinoic acid via retinal in the cell and regulate the expression of the target gene through binding to the retinoic acid receptor in the nucleus, and plays an important role in the regulation of cell differentiation and proliferation. I am in charge. In the skin, an action of promoting the production of epidermal hyaluronic acid and dermal collagen and an action of promoting epidermal turnover have been reported, and they are used for the treatment of wrinkles and pigmentation. However, the concentration at which these effects are efficiently exhibited has not been known in cosmetics.

Ascorbic acid (AsA) derivative nanocapsules can improve the stability and skin permeability of inclusion components. In addition, the coating of nanocapsules is composed of GO-VC, a novel amphipathic AsA derivative, and synergistic effects of GO-VC and inclusion components can be expected. Therefore, we report on the effects of 0.3% and 0.5% retinol-encapsulated AsA derivative nanocapsules prepared on wrinkles and pigmentation.

已知视黄醇通过细胞中的视黄醛转化为视黄酸，并通过与细胞核中的视黄酸受体结合来调节靶基因的表达，并且在调节细胞分化和增殖中起重要作用。我是负责人。在皮肤中，已经报道了促进表皮透明质酸和皮肤胶原蛋白产生的作用以及促进表皮周转的作用，并且它们被用于治疗皱纹和色素沉着。然而，在化妆品中尚不知道有效发挥这些作用的浓度。

抗坏血酸（AsA）衍生物纳米胶囊可以提高包合物成分的稳定性和皮肤渗透性。此外，纳米胶囊的包衣由新型两亲性AsA衍生物GO-VC组成，可以预期GO-VC与包合物的协同作用。因此，我们报道了制备的0.3％和0.5％视黄醇封装的AsA衍生物纳米胶囊对皱纹和色素沉着的影响。

Takeshi Nagata (IT O Pro Vitamin Research Center Co., Ltd.)

Whitening mechanism of new amphipathic ascorbic acid derivative GO-VC-its new mechanism of action-

GO-VC is a novel amphipathic AsA derivative with excellent stability in which glycerin and octanol are bound to ascorbic acid (AsA). Numerous cell and clinical trials have been conducted to elucidate its functionality, and its effects on acne vulgaris, wrinkles, pigmentation, etc. have been confirmed. In particular, regarding the whitening action mechanism, it was confirmed that it has a plurality of new action mechanisms different from those of conventional AsA derivatives. While AsA and conventional AsA derivatives suppress melanin production by inhibiting tyrosinase enzyme activity, GO-VC suppresses melanin production by reducing the amount of tyrosinase and the melanosome structural protein Pmel17. Furthermore, the transport of melanosomes to the vicinity of the cell membrane of melanocytes is suppressed, and the melanosomes accumulated around the nucleus are degraded by autophagy. This time, we will explain in detail the surprising whitening action mechanism of GO-VC, and also introduce the AsA derivative nanocapsule raw material with data.

GO-VC是一种新型两亲性AsA衍生物，具有出色的稳定性，其中甘油和辛醇与抗坏血酸（AsA）结合。已经进行了许多细胞和临床试验以阐明其功能性，并且已证实其对寻常性痤疮，皱纹，色素沉着等的影响。特别地，关于增白作用机理，已经证实其具有不同于常规AsA衍生物的许多新作用机理。 AsA和传统的AsA衍生物通过抑制酪氨酸酶的活性来抑制黑色素的产生，而GO-VC通过减少酪氨酸酶和黑素体结构蛋白Pmel17的含量来抑制黑色素的产生。此外，抑制了黑素体向黑素细胞的细胞膜附近的运输，并且通过自噬降解了聚集在核周围的黑素体。这次，我们将详细解释GO-VC令人惊讶的增白作用机理，并结合数据介绍AsA衍生物纳米胶囊的原料。

2019

118th Annual Meeting of the Japanese Dermatological Association Morning Seminar

Effect of amphipathic vitamin combination therapy on acne vulgaris

2019-06-08 08: 00-09: 00 Venue 6 Co-sponsored by: ITO Co., Ltd.

[Chair] Akira Kawada (Kinki Univ.)

MS5-1

Usefulness of new vitamin C and vitamin E lotions for PIH, PIE and AS due to acne vulgaris

[Performer] Ichiro Kurokawa: 1

1: Meiwa Hospital Dermatology

Post-inflammatory hyperpigmentation (post-inflammatory hyperpigmentation) in complications of acne vulgaris

There are pigmentation: PIH), post-inflammatory erythema (PIE), and atrophic scar (AS). Active ascorbic acid derivatives APPS (ascorbic acid palmitate 3Na). Water-soluble vitamin E derivatives: 3 against PIH, PIE, AS due to pockmark vulgaris using a lotion containing TPNa (sodium tocopheryl phosphate) A monthly left-right comparison test was conducted to examine the efficacy. For PIH, Pm, and AS. Vitamin C and Vitamin E-containing lotion was significantly more effective on the application side than on the non-application side. It was not found. Also, I would like to introduce the basic data of GOVC. The novel vitamin C and vitamin E combination lotion was considered to be a useful cosmetic for Pm, PIE and AS caused by pockmark vulgaris.

有色素沉着：PIH），炎症后红斑（PIE）和萎缩性瘢痕（AS）。活性抗坏血酸衍生物APPS（抗坏血酸棕榈酸酯3Na）。水溶性维生素E衍生物：使用含TPNa（生育酚磷酸钠）的乳液，对因寻常疱疹引起的PIH，PIE，AS产生3种抗药性。每月进行左右比较试验以检查疗效。用于PIH，Pm和AS。含维生素C和含维生素E的乳液在施用方面要比非施用方面有效得多。找不到。另外，我想介绍一下GOVC的基本数据。新型维生素C和维生素E组合乳液被认为是由寻常痘痘引起的Pm，PIE和AS的有用化妆品。

MS5-2

Does the effectiveness of transdermal preparations change depending on the formulation? (Take a new nanoparticle formulation as an example)

[Performer] Yoshihiro Tokudome: 1

1: Josai University Faculty of Pharmaceutical Sciences

The administration of a compound through the skin (transdermal administration) is a very excellent method of administration, but the medicinal effect may not be expected depending on the transdermal absorbability of the compound. It is important to secure the concentration of the compound at the target site and the residence time of the compound in the skin. Generally, the molecular weight and lipophilicity are important for transdermal absorbability. The skin of a compound having a large molecular weight or a high water solubility. Interpenetration is extremely low. Conversely, compounds with a small molecular weight or high lipophilicity have relatively good skin permeability. Water-soluble compounds have been attempted to improve skin penetration. On the other hand, in the case of lipophilic compounds. Sustained release may be required in order to expect medicinal effects. In this session, highly unique vitamin A nanoparticle preparations with high lipophilicity and hyaluronic acid nanoparticle preparations with large molecular weight are taken as examples. Introduces effective formulation design and outlines transdermal absorption of nanoparticles and formulation design.

通过皮肤施用化合物（透皮施用）是非常优异的施用方法，但是取决于化合物的透皮吸收性，可能无法预期药物作用。重要的是要确保化合物在目标部位的浓度以及化合物在皮肤中的停留时间。通常，分子量和亲脂性对于透皮吸收能力很重要。具有大分子量或高水溶性的化合物的皮肤。互穿性极低。相反，具有小分子量或高亲脂性的化合物具有相对良好的皮肤渗透性。已经尝试了水溶性化合物来改善皮肤渗透。另一方面，在亲脂性化合物的情况下。可能需要缓释以达到预期的医学效果。在本次会议中，以具有高度亲脂性的高度独特的维生素A纳米颗粒制剂和具有大分子量的透明质酸纳米颗粒制剂为例。介绍有效的配方设计，并概述纳米颗粒的透皮吸收和配方设计。

MS5-3

Delivery system for amphipathic vitamin C derivatives

[Performer] Azusa Utsuki: 1

1: IT O Pro Vitamin Research Center Co., Ltd.

Contents: Vitamin C has been used in many cosmetics because it is expected to have antioxidant and melanin production inhibitory effects. However, the stability of vitamin C is not good, and the color changes over time and the odor. There were many problems such as the occurrence of melanin. In addition, there was also a problem with compatibility with high polymers, and there was also the characteristic that the dosage form collapsed when blended in gel preparations. In recent years, vitamin C derivatives have improved these points. Is used in various preparations, and its melanin production inhibitory effect and type I collagen production promoting effect have already been reported. In addition, the stability and permeability of the contained components are achieved by using our patented vitamin derivative nanocapsules. In this seminar, we will report on the types of vitamin C derivatives and the system for delivering the inclusion components into the skin by nanoencapsulating them.

内容：维生素C已被用于许多化妆品中，因为它有望具有抗氧化和抑制黑色素生成的作用。但是，维生素C的稳定性不好，并且颜色会随着时间和气味而变化。存在许多问题，例如黑色素的出现。另外，还存在与高聚物的相容性的问题，并且还具有当掺入凝胶制剂中时剂型塌陷的特征。近年来，维生素C衍生物已改善了这些问题。用于各种制剂中，其黑色素生成抑制作用和I型胶原生成促进作用已有报道。此外，通过使用我们的专利维生素衍生物纳米胶囊，可以实现所含成分的稳定性和渗透性。在本研讨会中，我们将报告维生素C衍生物的类型以及通过纳米封装将包涵物成分递送到皮肤中的系统。

62nd Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery / Academic Meeting Luncheon Seminar 19

Effect of Vitamin C Preparations on Delivery System

Moderator: Professor Kazuo Kishi, Department of Plastic Surgery, Keio University School of Medicine

Okumura Clinic Director Chika Okumura

Title: Usefulness of amphipathic vitamin C derivative gels in plasma therapy

GOVC is an almighty ingredient that can deal with various skin problems, but I pay particular attention to the effects of "preventing and improving skin pigmentation" and "promoting collagen growth and regeneration" to prevent acne and acne scars. I often recommend it to patients who care about it. Since it is an ingredient that can be safely used by the younger generation, cosmetics containing GOVC are very suitable as the first cosmetics for beginners in skin care to choose. GOVC can be used by any age group, regardless of gender. Therefore, GOVC is used as the basis for many treatments and treatments at our hospital and adjacent medical esthetics. Always used to soothe the skin after laser toning or phototherapy (IPL) to improve age spots and dullness. Recently, we are using the universal type GOVC to perform electroporation using our original plasma. GOVC is amphipathic (amphipathic) that dissolves in both water and oil, giving the impression that it is easy on the skin. Plasma electroporation using this GOVC can be expected to brighten the skin tone, reduce wrinkles, and restore skin elasticity.

GOVC是一种全能成分，可以解决各种皮肤问题，但我特别注意“预防和改善皮肤色素沉着”和“促进胶原蛋白的生长与再生”的效果，以预防痤疮和痤疮疤痕。我经常向关心它的患者推荐它。由于它是年轻一代可以安全使用的成分，因此含有GOVC的化妆品非常适合作为皮肤护理初学者的首批化妆品。不论性别，GOVC均可用于任何年龄段。因此，GOVC被用作我们医院和邻近医学美学领域许多治疗方法的基础。激光调色或光疗（IPL）后常用于舒缓皮肤，以改善老年斑和暗沉。最近，我们正在使用通用型GOVC使用我们的原始血浆进行电穿孔。 GOVC是两亲性的（两亲性），可溶于水和油，给人的感觉是它很容易在皮肤上使用。使用该GOVC进行的血浆电穿孔有望使肤色变白，减少皱纹并恢复皮肤弹性。

Kaoru Clinic Director Kaoru Sato

Title: Effect of tranexamic acid inclusion nanosphere preparation

The effect on pigmented lesions was examined using a combination drug of tranexamic acid, vitamin C, and tocopheryl potassium ascorbic acid (EPC), which is a derivative of vitamin E. As a result of verification after 2 months of use, the change in brightness increased by about 10% compared to the placebo group. These results suggest that topical combination therapy of tranexamic acid and EPC lotion and cream is effective in improving pigmented lesions.

使用氨甲环酸，维生素C和维生素E的生育酚抗坏血酸钾（EPC）的联合药物检查了对色素沉着病变的影响。使用2个月后进行验证的结果是，亮度变化与安慰剂组相比，增加了约10％。这些结果表明，氨甲环酸和EPC乳液和乳膏的局部联合治疗可有效改善色素沉着病变。

Mayu Kurihara, Researcher, Vitamin Research Center, IT O Pro Co., Ltd.

Title: Delivery system for amphipathic vitamin C derivatives

2018

117th Annual Meeting of the Japanese Dermatological Association Morning Seminar

Date and time: Saturday, June 2, 2018 8: 15-9: 15

Location: RIHGA Royal Hotel Hiroshima 3F Aki

Themes: High moisturizing, antioxidants, cell proliferation and novel functional molecules

Forefront of next-generation cosmetic raw material development

ITO Co., Ltd.

[Chair] Akira Kawada (Kinki Univ.)

MS7-1

Efficiency of cell tissue transplantation by sustained-release nanofibers of cell growth factors

[Performer] Kenichi Nagase: 1

[Co-stars] Yuhei Nagumo: 1, MiriKim: 3, Hye-JinChung: 3, Shuichi Sekine: 2, Tatsuya Shimizu: 2, Hideko Kanazawa: 1, Teruo Okano: 2, Seung-Jin Lee: 3, Masayuki Yamato: 2

1: Faculty of Pharmaceutical Sciences, Keio University, 2: Institute of Advanced Biomedical Sciences, Tokyo Women's Medical University, 3: Department of Pharmacy, Ewha Womens University

Cell sheets composed of monolayer cells have various applications in regenerative medicine. A cell sheet made from cardiomyocytes can be laminated to make thick myocardial tissue, but in order to engraft in vivo, it is indispensable to construct a vascular network to supply oxygen and nutrients to cardiomyocytes. is there. Therefore, in this study, we investigated the promotion of vascular network construction on cardiomyocyte sheets by local sustained release of vascular endothelial growth factor (VEGF) in vivo. A fiber mat that releases VEGF slowly was transplanted under the skin of a rat together with a six-layered cardiomyocyte sheet, and the tissue two weeks after the transplantation was collected to evaluate the thickness of the cardiomyocyte sheet layer. As a result, it was found that a remarkably thick tissue was engrafted and a blood vessel having a large cross-sectional area was constructed. This indicates that it is possible to construct a thick myocardial tissue having a vascular network in vivo by slowly releasing VEGF in the vicinity of the cardiomyocyte sheet.

由单层细胞组成的细胞片在再生医学中有多种应用。可以将由心肌细胞制成的细胞片进行层压以形成厚的心肌组织，但是为了在体内植入，构建血管网络以向心肌细胞供应氧气和营养是必不可少的。在那儿。因此，在这项研究中，我们调查了通过局部持续释放体内血管内皮生长因子（VEGF）促进心肌细胞片上的血管网络构建。将缓慢释放VEGF的纤维垫与六层心肌细胞片一起移植到大鼠的皮肤下，并在移植两周后收集组织以评估心肌细胞片层的厚度。结果发现，移植了非常厚的组织，并且构造了具有大横截面积的血管。这表明可以通过在心肌细胞片附近缓慢释放VEGF来构建体内具有血管网络的厚心肌组织。

MS7-2

Research on the skin accommodative function of "Narsgen" from the viewpoint of inflammation control

[Performer] Kishi Tanaka: 1

[Co-star] Kazuo Matsumoto: 2, Ryuzo Yoshioka: 2

1: Inflammation Control Research Team, Center for Integrated Biomedical Sciences, RIKEN, 2: Knars Corporation

Narsgen is an aging skin care cosmetic material produced and sold by Nars Corporation, and is a derivative of an amino acid with a molecular weight of 330. It has been suggested that Narsgen increases skin moisturization and elasticity and restores normal skin function, but its detailed mechanism of action has not been clarified so far. We have a viewpoint of skin inflammation control. I tried to clarify from. The skin eliminates harmful stimuli from the outside world by inducing an inflammatory response and repairs damaged tissue. In this tissue repair process, the stimulation of a cytokine called TGFβ causes MMP, collagen, etc. Expression of various genes essential for tissue repair such as FGF and Amphiregulin is induced. We show that Narsgen, in collaboration with TGFβ, induces the expression of these genes to repair tissue, which is a late process of the inflammatory reaction. It was clarified that it regulates skin function by promoting the reaction. In this talk, I would like to discuss the molecular mechanism of action of collagen.

Narsgen是由Nars Corporation生产和销售的老化皮肤护理美容材料，是分子量为330的氨基酸的衍生物。有人建议Narsgen可以增加皮肤的保湿和弹性，并恢复正常的皮肤功能，但其详细信息到目前为止，作用机理尚未阐明。我们有控制皮肤炎症的观点。我试图澄清一下。皮肤通过引起炎症反应并修复受损的组织，从而消除了外界的有害刺激。在该组织修复过程中，刺激称为TGFβ的细胞因子会引起MMP，胶原蛋白等。诱导了组织修复必不可少的各种基因（例如FGF和双调蛋白）的表达。我们显示Narsgen与TGFβ协同诱导这些基因的表达来修复组织，这是炎症反应的后期过程。明确了它通过促进反应来调节皮肤功能。在本次演讲中，我想讨论胶原蛋白作用的分子机制。

MS7-3

Drug delivery system using amphipathic vitamin C derivatives

[Performer] Because of Lee: 1

[Co-star] Shinobu Ito: 1

1: ITO Co., Ltd.

Nanospheres, which we developed about 10 years ago, are multi-layered nanocapsules with a coating composed of amphipathic vitamin derivatives, in which the active ingredient can be encapsulated. Since the capsule film has an antioxidant effect, it is possible to enhance the stability and skin permeability of the enclosed active ingredient. APPS and the like have been used as the film component, but there are problems such as coloring due to instability. In recent years, stable GOVC has been developed and it has become possible to provide stable nanocapsules.

我们大约10年前开发的纳米球是多层纳米胶囊，其涂层由两亲性维生素衍生物组成，可以将活性成分封装在其中。由于胶囊膜具有抗氧化作用，因此可以提高封闭的活性成分的稳定性和皮肤渗透性。 APPS等已被用作膜成分，但是由于不稳定性而存在诸如着色的问题。近年来，已经开发了稳定的GOVC，并且已经可以提供稳定的纳米胶囊。

61st Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery Hands-on Seminar 2

Preparation of lamellar structure preparation (external preparation) that enhances skin barrier function three-dimensionally

Date and time April 12th (Thursday) 9: 15-11: 15

Place Hands-on Seminar Venue (Denki Building Kyosokan 3rd Floor D Small Conference Room)

Seminar content

Recently, there is a demand for external preparations for skin care with high moisturizing performance. The stratum corneum lipids of the human epidermis have a "lamellar" structure and retain a high barrier function. Lamellar means "layered", and a layered structure of water and oil exists between the stratum corneum cells. It is known that intercellular lipids not only exist as components, but also have a three-dimensional structure called lamella, which exerts a high barrier function. The lamellar structure is formed by a special amphipathic lipid molecule such as ceramide taking a liquid crystal structure together with an aqueous phase and an oil phase. This aqueous phase contains aqueous components such as amino acids called NMF (Natural Moisturizing Factor), which themselves have high moisturizing power and thus reinforce the barrier function of the skin. Recent advances in cosmetic emulsification technology have made it possible to artificially reproduce the three-dimensional structure of this lamella. The existence of the lamellar structure can be confirmed as a characteristic interference image under a polarizing microscope. In aged skin and rough skin, the barrier function of the skin may be deteriorated due to a lack of components constituting the lamella or a disorder of the lamellar structure itself. By applying an external preparation containing a three-dimensional lamellar structure composed of a water-soluble moisturizing factor, an amphipathic substance, and a lipid to the skin, it is possible to contribute to strengthening the barrier function of the skin. The purpose of this seminar is as follows. A highly moisturizing cream or gel is prepared using the ITO lamellar structure creation kit (ITO lamellar paste). Antioxidants such as fullerenes, vitamin C derivatives, astaxanthin, and coenzyme Q10 are encapsulated in the lamellar structure of the cream to prepare a highly functional preparation. Introducing clinical examples and basic data using nanosphere technology in which lamella paste is made into nano-sized fine particles.

近来，需要具有高保湿性能的用于皮肤护理的外部制剂。人表皮的角质层脂质具有“层状”结构并保持高屏障功能。层状的意思是“分层的”，并且在角质层细胞之间存在水和油的分层结构。已知细胞间脂质不仅作为组分存在，而且具有称为薄片的三维结构，其发挥高的屏障功能。层状结构是由特殊的两亲性脂质分子如神经酰胺形成的，该分子具有液晶结构以及水相和油相。该水相含有称为NMF（天然保湿因子）的氨基酸等水性成分，它们本身具有高保湿能力，因此可以增强皮肤的屏障功能。化妆品乳化技术的最新进展使得可以人工复制该薄片的三维结构。层状结构的存在可以在偏光显微镜下确认为特征干涉图像。在老化的皮肤和粗糙的皮肤中，皮肤的屏障功能可能由于缺少构成薄片的成分或薄片状结构本身的紊乱而恶化。通过将包含由水溶性保湿因子，两亲性物质和脂质组成的三维层状结构的外用制剂施用于皮肤，可以有助于增强皮肤的屏障功能。本研讨会的目的如下。使用ITO层状结构创建套件（ITO层状糊剂）可以制备高度保湿的霜剂或凝胶。将抗氧化剂（例如富勒烯，维生素C衍生物，虾青素和辅酶Q10）封装在乳膏的层状结构中，以制备功能强大的制剂。使用纳米球技术介绍临床实例和基本数据，其中将薄片糊制成纳米尺寸的细颗粒。

We will also introduce other ITO products such as oral supplements to increase the moisturizing properties of the skin.

Moderator Kazuo Kishi (Professor, Department of Plastic Surgery, Keio University School of Medicine)

Performer / Lecturer Kaoru Sato (Kaoru Clinic)

Yue　Lee (ITO Co., Ltd.)

Co-sponsored by ITO Co., Ltd.

2017

116th Annual Meeting of the Japanese Dermatological Association Morning Seminar 6 Venue 6 (Sendai International Center)

Date and time: Saturday, June 3, 2017

Co-sponsored by the 116th Annual Meeting of the Japanese Dermatological Association / ITO Co., Ltd.

Seminar theme: Photoaging measures and safety of nano-UV shielding material

Moderator: Professor Akira Kawada, Department of Dermatology, Kinki University School of Medicine

■ Do you know about industrial nanomaterials and their biological effects?

Speaker: Osamu Yamamoto (Professor, Department of Dermatology, Department of Sensory and Motor Medicine, Tottori University School of Medicine)

Nanomaterials generally refer to substances with a diameter of at least one dimension of the three-dimensional structure of primary particles of 100 nm or less. Compared to the bulk state of such substances, both the surface effect and the quantum effect are different, and as a result, the physical and chemical reactivity are different. In recent years, industrial technologies that utilize the properties of nanomaterials to bring many benefits to various fields of society have made remarkable progress, and the products of these technologies are already overflowing around us, but on the other hand, nanomaterials Is assumed to be a complex form of exposure to the human body, and due to its characteristics, concerns about health problems are also whispered. The future of nanotechnology depends on risk vs. the public interest, and unlike asbestos in the past, unlimited use without risk assessment is no longer allowed. After giving a general explanation of industrial nanomaterials, we will discuss the characteristics and risk assessment of titanium dioxide nanoparticles used in many sunscreens, as well as research conducted as part of NEDO's nanoprojects.

纳米材料通常是指直径为一次粒子的三维结构的至少一维的直径为100nm或更小的物质。与这些物质的整体状态相比，表面效应和量子效应均不同，因此，其物理和化学反应性也不同。近年来，利用纳米材料的特性为社会各个领域带来许多好处的工业技术取得了显着进步，这些技术的产品已经在我们周围泛滥，但是，另一方面，纳米材料被认为是一种新兴的技术。由于暴露于人体的复杂形式，并且由于其特性，对健康问题的担忧也悄悄地出现了。纳米技术的未来取决于风险与公共利益，与过去的石棉不同，不再允许未经风险评估的无限制使用。在给出了工业纳米材料的一般解释之后，我们将讨论许多防晒霜中使用的二氧化钛纳米颗粒的特性和风险评估，以及作为NEDO纳米项目的一部分而进行的研究。

■ Latest information on UV shielding agents: Nanotitanium oxide specs as seen from European cosmetic regulations

Speaker: Dr. Ryosuke Sugihara (Director, Okayama Research Institute, TAYCA Corporation)

Already more than 10 years ago, many organizations in Europe and the United States issued reports on the safety of nanotechnology in quick succession, and discussions on the safety of nanomaterials became active in each country including Japan. It was a discussion at various levels such as related companies, industries, countries, economic regions, etc., but in the end, how should we manage the risks associated with it while enjoying the great benefits of using nanomaterials? It was the focus. In 2016, the European Cosmetics Regulations were revised to officially allow up to 25% of nanotitanium oxide in sunscreen products. The impact of this conclusion in Europe, where the discussion of nanomaterials is most advanced, is enormous. In this lecture, we will give an overview of the specifications required for titanium oxide as seen from this revised content, and describe the compatibility and superiority of our products. In addition, we will also introduce products that focus on water-based and gel prescriptions, which are the trend of sunscreen prescriptions in recent years.

早在十多年前，欧洲和美国的许多组织就陆续发布了有关纳米技术安全性的报告，有关纳米材料安全性的讨论在包括日本在内的每个国家都开始活跃。在相关公司，行业，国家，经济地区等各个层面进行了讨论，但最后，在享受使用纳米材料的巨大好处的同时，我们应如何管理与之相关的风险？这是重点。 2016年，对《欧洲化妆品法规》进行了修订，正式允许防晒产品中最多含25％的纳米氧化钛。这一结论在欧洲，对纳米材料的讨论最为先进的影响是巨大的。在本讲座中，我们将从修订后的内容中概述氧化钛所需的规格，并描述我们产品的兼容性和优越性。此外，我们还将介绍针对水性和凝胶处方的产品，这是近年来防晒处方的趋势。

The 60th Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery

Date and time April 12 (Wednesday) 15: 00-17: 00

Place Osaka International Convention Center 10F Conference Room 1007

Demonstration of preparation of external preparation for UV care

Moderator Kazuo Kishi (Keio University School of Medicine, Department of Plastic Surgery)

Performer / Lecturer Koichi Yamaji (Tayca Corporation Okayama Research Institute)

Dr. Masayuki Ito (Vitamin C60 Bioresearch Co., Ltd.)

Because of Lee (ITO Co., Ltd.)

Co-sponsored by ITO Co., Ltd.

Seminar contents In recent years, the effects of ultraviolet rays on photoaging and skin cancer have been discussed, and the demand for sunscreens has been increasing year by year, and many products are on the market. On the other hand, UV protection is also an important issue after treatment such as post-laser care, and the need for more sophisticated external sunscreen preparations is increasing. However, the sunscreen preparations that are actually on the market do not have sufficient performance, and there are many hopes that they can adjust themselves. Therefore, at this hands-on seminar, we will explain the non-chemical (UV absorber-free) type BB (BlemishBalm) cream that even beginners can easily make and have a high sunscreen effect, and make cream using the raw material kit. All participants will experience it. In addition, researchers from manufacturers will directly explain the latest information on the latest UV shielding materials and antioxidant materials (fullerenes, stable vitamin C derivatives, etc.) that are recommended for use in sunscreen products.

研讨会内容近年来，已经讨论了紫外线对光老化和皮肤癌的影响，并且对防晒霜的需求逐年增加，并且有许多产品在市场上。另一方面，在诸如激光后护理之类的治疗之后，紫外线防护也是重要的问题，并且对更复杂的外部防晒剂的需求也在增加。然而，实际上在市场上出售的防晒制剂没有足够的性能，并且有许多希望它们可以自我调整。因此，在本动手研讨会上，我们将介绍即使初学者也可以轻松制造并具有很高防晒效果的非化学（无紫外线吸收剂）BB型（BlemishBalm）乳霜，并使用原材料套件制造乳霜。所有参与者都将体验到。此外，制造商的研究人员将直接解释建议用于防晒产品的最新紫外线屏蔽材料和抗氧化剂材料（富勒烯，稳定的维生素C衍生物等）的最新信息。

EADV (European Dermatological Association) Geneva, Switzerland

Glyceryl-octyl-ascorbic acid (GOVC), a novel stable amphiphilic ascorbic-acid derivative is an alternative adjuvant available cosmetic agent for acne　vulgaris

Ichiro Kurokawa 1), Satsuki Osame 2), Masato Yoshioka 3), Shinobu Ito 4)5), and Hideko Kanazawa 5)

1) Meiwa Hospital, Agenaruo-cho, Nishinomiya, Hyougo Japan 663-8186. 2) Osame-skinclinic, 2-17-8, Ebisu-nishi, Shibuya-ku, Tokyo Japan 150-0021. 3) Seiwa Kasei Co. Ltd., 1-2-14 Nunoichi-cho, Higashiosaka. Osaka, Japan 579-8004, 4) I.T.O. Co.Ltd., 1-19-2-2F, Naka-cho, Musashino, Tokyo Japan 180-0006. 5) Faculty of Pharmacy, Keio University; Minato, Tokyo, Japan 105-0011.

Acne vulgaris is a multifactorial disease that develops at puberty. Coproporphyrin produced by Propionibacterium acnes (P. acnes) induces reactive oxygen species and promotes inflammation. In recent years, the several effects of ascorbic-acid (AsA) derivatives having an antioxidant activity for the treatment of acne vulgaris have been reported. Based on these reports, two AsA derivatives are recommended as option (C1) as cosmetic active agents for Japanese guideline for the treatment of acne vulgaris published by the Japanese Society of Dermatology in 2016. Glyceryl-octyl-ascorbic acid (GOVC) was developed for obtaining a significant effect on acne vulgaris. GOVC is a novel, amphiphilic stable AsA derivative with an antimicrobial activity. In this study, the stability, antioxidant effect, and antimicrobial activity by GOVC were investigated. In addition, clinical trials using topical GOVC were performed and its efficacy and adverse effects were evaluated on acne lesions.

(1) One percent GOVC aqueous solution showed a high stability of 98% or more without odor, discoloring, and precipitation after the storage test at 40 °C for 6 months. The residual ratio after autoclave treatment was more than 91%. (2) Radical scavenging activity of GOVC (0.1% solution) significantly decreased the amount of O2* down to 60.5% (n = 7, p <0.01) compared with that of the control. (3) In the chlorine radical scavenging activity test, GOVC (0.1% solution) significantly decreased the amount of chlorine radical down to 13.5% (n = 7, p ><0.01) compared to that of the control. (4) 0.1% GOVC showed an antimicrobial effect against P. acnes. (5) Topical GOVC was clinically effective for acne lesions. Using analyzing the number of automatically identified acne lesions, red inflammatory papules decreased significantly down to 55% (p ><0.05), and its area of postinflammatory erythema significantly decreased down to 32% (p >< 0.05).

　A high stability, and an antioxidant and antimicrobial effects against P.acnes of GO-VC were confirmed. The clinical trials demonstrated that the number of inflammatory lesions and area of postinflammatory erythema were decreased significantly by topical GOVC. No adverse effects using topical GOVC were observed.　Therefore, GOVC can be an alternative adjuvant available cosmetic agent for acne vulgaris.

2016

The 115th Annual Meeting of the Japanese Dermatological Association Morning Seminar

Date and time: Saturday, June 4th, 8: 15-9: 15

Seminar No: Morning Seminar 2

Theme: Acne Treatment Strategies Using New Vitamin C Derivatives

Venue: Kyoto International Conference Center 5th Venue (2FRoomB-2)

Chair: Akira Kawada (Professor, Department of Dermatology, Kinki University School of Medicine)

Subject 1: New Strategy for Acne Treatment-combination Treatment with New Vitamin C Derivatives

Speaker name: Dr. Ichiro Kurokawa (Director, Department of Dermatology and Acne Center, Meiwa Hospital)

In 2015, acne treatment in Japan entered a new era with the advent of BPO preparations. However, we often experience cases of boil that are ineffective with drug treatment. In our department, we are effective in treating intractable acne by combining chemical peeling with glycolic acid and self-financed medical care by iontophoresis including novel vitamin C derivatives. For chemical peels

Therefore, it is speculated that the drug penetrates into the hair follicle and the drug can exert its effect more effectively. The novel vitamin C derivatives are amphipathic and easily reach the hair follicles, and are thought to exert antioxidant effects, melanin production suppression, and fibroblast activation effects. Vitamin A may have an inhibitory effect on keratinization, and vitamin E may have an inhibitory effect on lipid peroxide. These treatments are effective not only for inflammatory and non-inflammatory lesions, but also for post-inflammatory hyperpigmentation, which is a complication. In the future, combination treatment by chemical peeling and iontophoresis is considered to be an effective adjunctive treatment for acne.

2015年，随着BPO制剂的出现，日本的痤疮治疗进入了一个新时代。但是，我们经常会遇到因药物治疗无效而导致烧开的案例。在我们的部门，我们通过将化学去皮与乙醇酸相结合以及通过离子电渗疗法（包括新型维生素C衍生物）的自负盈亏医疗服务，有效地治疗了顽固性痤疮。用于化学果皮

因此，推测该药物渗透到毛囊中并且该药物可以更有效地发挥其作用。新型的维生素C衍生物具有两亲性，易于到达毛囊，并被认为具有抗氧化作用，抑制黑色素生成和成纤维细胞活化作用。维生素A可能对角质化有抑制作用，维生素E可能对脂质过氧化物有抑制作用。这些治疗不仅对于炎性和非炎性病变有效，而且对于炎性色素沉着过度也是一种并发症。将来，通过化学剥离和离子电渗疗法的组合治疗被认为是痤疮的有效辅助治疗。

Subject (2): How to use a wide variety of vitamin C derivative cosmetics

Name of performer: Yue Lee (Researcher, IT O Pro Vitamin Research Center Co., Ltd.)

Vitamin C derivatives are effective for acne vulgaris and post-laser care, but the number of them has increased in recent years, and it is often said that it is difficult to understand what to use and how to use them. In addition, there are problems peculiar to vitamin C preparations such as stability problems, poor usability, and dry skin, and countermeasures are required. By knowing the characteristics of each vitamin C derivative and using it properly, it becomes possible to use it more effectively. This time, we will introduce the basics of various vitamin C derivatives and how to use them by type.

维生素C衍生物对寻常痤疮和激光治疗后有效，但近年来它们的数量有所增加，并且经常说很难理解使用方法和用法。另外，存在维生素C制剂特有的问题，例如稳定性问题，使用性差和皮肤干燥，因此需要对策。通过了解每种维生素C衍生物的特性并正确使用它，可以更有效地使用它。这次，我们将介绍各种维生素C衍生物的基础知识以及如何按类型使用它们。

2016年

The 59th Japan Society of Plastic and Reconstructive Surgery / Academic Meeting Luncheon Seminar

Date and time: Wednesday, April 13th, 12: 10-13: 10

Seminar No: Luncheon Seminar 5 Theme: Characteristics of various vitamin C derivatives and their applications

Venue: Fukuoka International Congress Center 5th Venue (4F411 + 412 Conference Room) (Please refer to the attached guide map)

Chair: Dr. Kazuo Kishi (Professor, Department of Plastic Surgery, Keio University School of Medicine)

Co-sponsored by: ITO Co., Ltd.

○Effects of Vitamin C Derivatives on Downtime After Laser

Name of performer: Dr. Ayako Mori (Director of Clinic Mori)

○Effect of tranexamic acid-encapsulated nanocapsule formulation　 Name of performer: Kaoru Sato (Director of Kaoru Clinic)

○How to use a wide variety of vitamin C derivatives cosmetics　

Name of performer: Yue Lee (Researcher, IT O Pro Vitamin Research Center Co., Ltd.)

She talked about the effect of glyceryl octyl ascorbic acid (GOVC), a new amphipathic vitamin C developed by the company, on inflammatory pigmentation that may occur after laser treatment. Normal vitamin C is water-soluble and relatively difficult to be absorbed by the skin, but the addition of lipids and alcohol can also improve skin permeability.　However, it is difficult to achieve both stability and absorbability with conventional lipid-added derivatives, and GOVC has solved this difficult problem. GOVC is an amphipathic vitamin C derivative having a structure in which glycerin is bound to the hydroxyl group at the 2-position of vitamin C and octanol is bound to the hydroxyl group at the 3-position. The feeling of stickiness and tension, which was difficult with conventional vitamin C derivatives, has also been improved, and the common sense of vitamin C has been changed.　 Furthermore, GOVC was found to have strong antibacterial activity, and was found to have an inhibitory effect on not only P. acnes, which is the cause of acne, but also Escherichia coli and Staphylococcus aureus. A fibroblast activating effect and a collagen production promoting effect, which can be expected to improve wrinkles and sagging, were also confirmed, and a melanin production suppressing effect was confirmed as a whitening effect, and a hair protection effect against chlorine damage was also confirmed as a hair care-related effect. It can be blended not only in basic cosmetics such as lotions, serums, creams, and gels, but also in a wide range of cosmetic base materials such as hair care applications.

他谈到了该公司开发的一种新的两亲性维生素C甘油基辛基抗坏血酸（GOVC）对激光治疗后可能发生的炎性色素沉着的影响。正常的维生素C是水溶性的，相对难以被皮肤吸收，但是通过添加脂质和醇类可以改善皮肤的渗透性。然而，用常规的添加脂质的衍生物难以同时获得稳定性和吸收性，并且GOVC解决了该难题。 GOVC是具有两性结构的维生素C衍生物，其中甘油在维生素C的2-位与羟基结合，辛醇在3-位的羟基与羟基结合。传统的维生素C衍生物难以达到的粘腻感和紧张感也得到了改善，并且维生素C的常识也发生了变化。此外，发现GOVC具有强的抗菌活性，并且发现其不仅对痤疮的致病因子痤疮丙酸杆菌具有抑制作用，而且对大肠杆菌和金黄色葡萄球菌也具有抑制作用。还证实了预期可以改善皱纹和下垂的成纤维细胞活化作用和胶原蛋白产生促进作用，并且证实了黑色素产生抑制作用为增白作用，并且还证实了针对氯损伤的护发作用为。与护发有关的效果。它不仅可以掺入基本化妆品中，例如乳液，精华液，乳霜和凝胶中，还可以掺入多种化妆品基础材料中，例如护发产品。

IFSCC (International Conference of Cosmetic Engineers) Florida, USA

Glyceryl-octylascorbicacid(GO-VC)havingahighersensory-texture-scoreobtainingabilityanditsefficacyonacneandskinpigmentation

Effect of glyceryl octyl ascorbic acid (GO-VC) with high sensory evaluation performance on acne and color pigmentation

YueRi1,ShinobuIto1,SatsukiOsame2,KaoruSato3,AyakoMori4

1)I.T.O.Co.,Ltd.,Tokyo,Japan,2)OsameSkinClinic,Tokyo,Japan,3)KaoruClinic,Tokyo,Japan,4)ClinicMori,Tokyo,Japan,

Glyceryl octyl ascorbic acid (GO-VC) is a stable amphipathic AsA derivative in which glycerin and octanol are bound to the water hydroxyl groups at the 2- and 3-positions of vitamin C (AsA), respectively.　

Our previous studies have already reported that GO-VC has a high stability, a fibroblast growth-promoting effect, and a type I collagen growth-promoting effect to improve wrinkles.

Since GO-VC binds octanol, which has antibacterial activity, it may exert antibacterial activity against P. acnes (P. acnes), which is involved in the development of acne vulgaris (acne).

This time, we investigated the effect of GO-VC on the growth of P. acnes and the effect of suppressing the production of melanin. We also conducted a clinical trial of GO-VC to examine its effect on acne, erythema, and color pigmentation. Furthermore, although conventional AsA and AsA derivatives have been reported to be used as a side effect to dry the skin abnormally, the moisturizing effect of GO-VC was also investigated.　As a result, GO-VC exhibited a high acne-improving effect as a result of in vitro and clinical trials, and it is considered that this may be related to the effect of GO-VC on the growth of P. acnes of the okotanol group. In addition, a high improvement effect on pigmentation and wrinkles was confirmed, suggesting that GO-VC may be highly effective as a cosmetic ingredient for home care for acne, pigmentation and wrinkles.　 Furthermore, the results of sensory tests are different from conventional ascorbic acid derivatives because GO-VC gives a good and good moisturizing feeling without squeaks and stickiness, which are peculiar side effects of conventional vitamin C preparations. It was confirmed that it is a vitamin C derivative that has high stability, high acne improvement effect, and high sensory evaluation performance. This was considered to be an effect derived from the harmony of the octanol group and the glycerin group of GO-VC.

甘油辛基抗坏血酸（GO-VC）是一种稳定的两亲性AsA衍生物，其中甘油和辛醇分别与维生素C（AsA）的2位和3位的水羟基键合。我们以前的研究已经报道，GO-VC具有高稳定性，促进成纤维细胞生长的作用以及改善皱纹的I型胶原生长的作用。

由于GO-VC结合具有抗菌活性的辛醇，因此它可能对痤疮丙酸杆菌（P. acnes）发挥抗菌活性，而痤疮丙酸杆菌与寻常痤疮（痤疮）的发展有关。

这次，我们研究了GO-VC对痤疮丙酸杆菌生长和抑制黑色素生成的影响。我们还进行了GO-VC的临床试验，以检查其对痤疮，红斑和色素沉着的影响。此外，尽管已经报道了使用常规的AsA和AsA衍生物作为异常干燥皮肤的副作用，但是还研究了GO-VC的保湿效果。

结果，通过体外和临床试验，GO-VC显示出高的痤疮改善作用，并且认为这可能与辛醇基团抑制痤疮丙酸杆菌的生长的作用有关。另外，由于已经证实其对颜色沉积和皱纹具有高的改善效果，因此建议将GO-VC作为用于痤疮，色素沉着和皱纹的家庭护理的化妆品成分显示出高有效性。此外，感官测试的结果表明没有吱吱声或粘性，这是常规维生素C制剂的特有副作用，并且GO-VC具有良好的保湿感，不同于常规的抗坏血酸衍生物并且高度证实了这是一种具有性别，高痤疮改善效果和高感官评价性能的维生素C衍生物。认为这是源自GO-VC的辛醇基和甘油基的和谐的效果。

2015

In 2015、CITE-JAPAN2015、Exhibitor technology presentation

Date: June 4, 2015 (Thursday)

Place : Pacifico Yokohama

Title: Surprising effect and stability! New amphipathic vitamin C derivatives GO-VC-clinical application to acne and whitening

Presenter: Yui Yoshii (ITO Co., Ltd.)

Abstract: Glyceryl octyl ascorbic acid (GO-VC) is a highly stable amphipathic vitamin C derivative with glycerin at the 2-position and octanol at the 3-position of vitamin C. It is considered that glycerin reduces the feeling of dryness and octanol has an antibacterial activity. Since the effects of inhibiting the growth of P. acnes and suppressing the production of melanin have been confirmed, we report the results of a clinical trial that examined the effects on acne, age spots, and wrinkles using a GO-VC combination preparation.

摘要：甘油基辛基抗坏血酸（GO-VC）是一种高度稳定的两亲性维生素C衍生物，在维生素C的2位甘油和3位的辛醇。认为甘油降低了干燥感，并且辛醇具有抗菌活性。由于已经证实抑制痤疮丙酸杆菌的生长和抑制黑色素的产生，我们报告了一项临床试验的结果，该研究使用GO-VC组合制剂检查了对痤疮，老年斑和皱纹的影响。

In 2015、The 114th Annual Meeting of the Japanese Dermatological Association, General Presentation

Date : May 30, 2015 (Saturday)

Place : Pacifico Yokohama

Title: New amphipathic vitamin C derivative glyceryl octyl ascorbic acid therapeutic effect on acne vulgaris

Presenters: Satsuki Natsuki (Osame Skin Clinic, Director), Yui Yoshii (ITO Co., Ltd.), Takeshi Nagata (ITO Co., Ltd.), Shinobu Ito (ITO Co., Ltd.)

Abstract: In recent years, vitamin C (AsA) is said to be useful for the treatment of wrinkles, post-inflammatory hyperpigmentation, acne vulgaris, etc., and is widely used in medical institutions. However, AsA is not stable, and when the concentration is high, a feeling of irritation or dryness may appear. This time, we investigated the effect of a novel AsA derivative (GO-VC) in which glycerin and octanol are bound to AsA on acne vulgaris. GO-VC has good skin penetration and may be effective at relatively low concentrations. In addition, since GO-VC has glycerin bound to it, it is considered that the feeling of dry skin is alleviated by glycerin. This time, when the effect on acne vulgaris was examined using a 0.1% GO-VC preparation, a good improvement effect was observed. It is highly possible that this was exerted not only by the antioxidant and anti-inflammatory effects of AsA, but also by the antibacterial effect of octanol. In the future, we will also consider the effect on pigmentation and wrinkles. ]

摘要：近年来，维生素C（AsA）被认为可用于治疗皱纹，炎症后色素沉着，寻常性痤疮等，并已在医疗机构中广泛使用。然而，AsA不稳定，并且当浓度高时，可能会出现刺激或干燥的感觉。这次，我们研究了一种新型AsA衍生物（GO-VC）的作用，其中甘油和辛醇与寻常型痤疮的AsA结合。GO-VC具有良好的皮肤渗透性，并且在相对较低的浓度下可能有效。另外，由于GO-VC结合有甘油，因此认为甘油可以减轻皮肤干燥的感觉。这次，当使用0.1％GO-VC制剂检查对寻常痤疮的作用时，观察到良好的改善作用。这很可能不仅是由于AsA的抗氧化和抗炎作用，还在于辛醇的抗菌作用。将来，我们还将考虑对色素沉着和皱纹的影响。

In 2015、The 114th Annual Meeting of the Japanese Dermatological Association, Morning Seminar Date : May 30, 2015 (Saturday)

Place : Pacifico Yokohama

Chair: Professor Akira Kawada, Department of Dermatology, Kinki University

＜Lecture1＞

Title: Examination of the effect of GO-VC on acne vulgaris, pigmentation and wrinkles

Presenter: Ayako Mori (Clinic Mori, Director)

Abstract: High-concentration vitamin C lotion is used for the treatment of wrinkles / sagging, post-inflammatory hyperpigmentation and acne vulgaris. However, there are problems that the activity of vitamin C is easily lost over time, and that when the vitamin C concentration is high, a feeling of irritation and dryness appear. Here, we report that the vitamin C derivative GO-VC, which is vitamin C with glycerin and octanol, had a good effect on the treatment of acne vulgaris even at a low concentration of 0.1%. It is highly possible that this was exerted not only by the antioxidant and anti-inflammatory effects of vitamin C, but also by the antibacterial effect of octanol. This drug has good skin permeability, and it is easy to obtain the effect at a relatively low concentration. In addition, since the feeling of dry skin due to the suppression of sebum secretion, which is a drawback of vitamin C lotion, is alleviated by glycerin, it can be said that it is a preparation that makes it easier to obtain the skin-beautifying effect of vitamin C. This time, we also examined the effects on pigmentation and wrinkles, and report them together.

摘要：高浓度维生素C洗剂用于治疗皱纹/下垂，发炎后色素沉着和寻常痤疮。然而，存在这样的问题，即维生素C的活性容易随着时间的流逝而丧失，并且当维生素C浓度高时，会出现刺激感和干燥感。在这里，我们报道了维生素C衍生物GO-VC，即含有甘油和辛醇的维生素C，即使在0.1％的低浓度下也对寻常痤疮具有良好的治疗效果。这很可能不仅是由于维生素C的抗氧化和抗炎作用，还在于辛醇的抗菌作用。该药物具有良好的皮肤渗透性，并且在较低浓度下易于获得效果。另外，由于甘油可减轻由于抑制皮脂分泌而引起的皮肤干燥感，这是维生素C乳液的缺点，因此可以说这是一种易于获得美化皮肤的制剂。维生素C的作用这次，我们还检查了对色素沉着和皱纹的影响，并将它们一起报告。

Co-sponsored by: ITO Co., Ltd.

＜Lecture2＞

Title: Effect and application of GO-VC on acne vulgaris

Presenter: Satsuki (Osame Skin Clinic, Director)

Abstract: The new amphipathic vitamin C derivative "glyceryl octyl ascorbic acid (GO-VC)" is expected to have high stability, transdermal absorption, moisturizing and antibacterial properties due to the binding of glycerin and octanol to vitamin C. Has been done. In addition, in tests using cells, melanin production inhibitory effect, fibroblast proliferation effect and collagen production promoting effect have also been confirmed, so even when it is actually applied to human skin and absorbed percutaneously. It is thought that the same effect can be expected. Therefore, this time, we investigated the effect of this GO-VC on acne vulgaris. As a result, a very remarkable reduction effect was confirmed, especially for redness. In addition, we will also examine the beauty effect of using three types of vitamins in combination using a gel preparation containing GO-VC and fat-soluble vitamin C derivatives "ascorbyl tetrahexyl decanoate (VCIP)" and "nicotinamide (vitamin B3)". I went there, so I will report it as well.

摘要：由于甘油和辛醇与维生素C的结合，新型两亲性维生素C衍生物“甘油基辛基抗坏血酸（GO-VC）”有望具有高稳定性，透皮吸收，保湿和抗菌特性。另外，在细胞试验中，也确认了抑制黑色素产生，成纤维细胞增殖和促进胶原产生的作用，因此，即使将其实际应用于人体皮肤并经皮吸收，也可以期待同样的效果。因此，这次，我们调查了这种GO-VC对寻常痤疮的影响。结果，证实了非常显着的还原效果，特别是对于发红。此外，我们还将研究结合使用三种类型的维生素的美容效果，这些凝胶与含有GO-VC和脂溶性维生素C衍生物“抗坏血酸四己基癸酸酯（VCIP）”和“烟酰胺（维生素B3）”的凝胶制剂结合使用。我去了那里，所以我也会报告。

Co-sponsored by: ITO Co., Ltd.

＜Lecture3＞

Title: How to use vitamin C derivatives according to skin

Presenter : Takeshi Nagata (ITO Co., Ltd)

Abstract: Vitamin C is very effective for our skin because it is highly effective against acne vulgaris, pigmentation and wrinkles. On the other hand, it is known that vitamin C has poor stability, and when applied to the skin, it is converted into a kind of active oxygen vitamin C radical by ultraviolet rays and the like. In other words, vitamin C, which is originally beneficial to the skin, may adversely affect the skin. Vitamin C derivatives have been developed to overcome these shortcomings of vitamin C. Currently, there are numerous types of vitamin C derivatives. For example, there are water-soluble ascorbic acid phosphate (AP), fat-soluble ascorbyl palmitate (VCIP), amphipathic glyceryl octyl ascorbic acid (GO-VC) and ascorbyl palmitate 3Na (APPS). To do. This time, we will introduce how to use these various vitamin C derivatives according to skin.

摘要：维生素C对我们的皮肤非常有效，因为它对寻常痤疮，色素沉着和皱纹非常有效。另一方面，已知维生素C具有较差的稳定性，并且当被施用到皮肤上时，它会被紫外线等转化为一种活性氧维生素C自由基。换句话说，原本对皮肤有益的维生素C可能会对皮肤产生不利影响。已经开发出维生素C衍生物来克服维生素C的这些缺点。当前，有多种类型的维生素C衍生物。例如，有水溶性抗坏血酸磷酸酯（AP），脂溶性抗坏血酸棕榈酸酯（VCIP），两亲性甘油基辛基抗坏血酸（GO-VC）和抗坏血酸棕榈酸酯3Na（APPS）。

这次，我们将介绍如何根据皮肤使用这些多种维生素C衍生物。

Co-sponsored by: ITO Co., Ltd.

Journal of Japanese Dermatological Association 124, p772, P1-8

Mechanism of toxicity expression of antioxidant molecules in pigment cells

Takeshi Nagata 1,2), Shinobu Ito 1), Kazuyoshi Itoga 2), Teruo Okano 2) (ITO Co., Ltd. 1), Tokyo Women's Medical University Institute for Advanced Biomedical Sciences 2))

In the past, we have reported that the increase in AA radicals and reactive oxygen species (ROS) due to high-concentration vitamin C (AA) in UV-irradiated skin tissue may be due to iron proteins. Lactone ring: AA and AA "2" phosphate (AP), benzene ring: Raspberry ketone (RK) and fullerene (FR) in epidermal keratinized cells (HC) and pigment cells containing high concentrations of copper protein tyrosinase (B16) The relationship between H2O2 and ROS production and cytotoxicity was investigated. As a result, intracellular ROS was significantly increased and toxicity was exhibited by high-concentration AP and RK treatment. However, only RK expressed higher toxicity in B16 compared to HC, and ROS was significantly increased only in B16 at this time. ROS production was suppressed by low-concentration FR, AP, EDTA (metal sequestering) treatment. From this result, high-concentration AP, RK treatment induces cell death by ROS production, but is characteristic of RK pigment cells. Toxicity was also suggested to be associated with intracellular ROS levels.

过去，我们曾报道说，紫外线辐射皮肤组织中高浓度的维生素C（AA）会导致AA自由基和活性氧（ROS）的增加，这可能是由于铁蛋白造成的。内酯环：AA和AA“含有高浓度铜蛋白酪氨酸酶（B16）的表皮角质化细胞（HC）和色素细胞中的2“磷酸盐（AP），苯环：树莓酮（RK）和富勒烯（FR）调查。结果，高浓度的AP和RK处理可显着增加细胞内ROS并显示出毒性，但是，只有RK在B16中的毒性高于HC，此时ROS仅在B16中显着增加。低浓度的FR，AP，EDTA（金属螯合剂）处理可抑制高浓度的AP，RK处理，诱导ROS产生细胞死亡，但它是RK色素细胞的特征，也被认为与毒性相关与细胞内ROS水平有关。

In 2015、The 58th Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery

Date : April 9, 2015

Place : Westin Miyako Hotel Kyoto

Title: Examination of the effect of GO-VC on acne vulgaris, pigmentation, and wrinkles

Presenter: Ayako Mori (Clinic Mori, Department of Plastic Surgery, Keio University)

Title: Examination of cosmetological effects by combining 3 types of vitamins, GOVC, VCIP, and vitamin B3

Performer: Kaoru Sato (Director of Kaoru Clinic)

Title: How to use vitamin C derivatives for different skin types

Performer : Yui Yoshii (ITO Co., Ltd.)

In 2015、The 58th Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery / Academic Meeting, General Presentation

Date : April 8, 2015 (Wednesday)

Place : Westin Miyako Hotel Kyoto

Title: New amphipathic vitamin C derivative glyceryl octyl ascorbic acid for acne treatment Presenters: Ayako Mori (Clinic Mori, Department of Plastic Surgery, Keio University), Takeshi Nagata (ITO Co., Ltd.), Yui Yoshii (ITO Co., Ltd.), Shinobu Ito (Keio University Faculty of Pharmaceutical Sciences) Department of Pharmaceutical Physics and Chemistry, ITO Co., Ltd.), Kazuo Kishi (Keio University Department of Plastic Surgery)

Abstract:

Purpose: In recent years, the number of patients who visit a cosmetic dermatologist for the purpose of treating acne is increasing. Prescriptions such as adapalene and nadifloxan have become common in medical insurance, and there is increasing interest not only in treating acne but also in improving it and maintaining a good condition. n cosmetology dermatology, regardless of insurance medical treatment, chemical peeling, fractional laser, etc., retinoid oral administration, co-examination with gynecology, etc. are considered depending on the symptom. Among them, vitamin C lotion tends to be the first choice for skin care, and is actively promoted to patients who are concerned about mild acne and pores. Depending on the concentration, it is used to treat post-inflammatory hyperpigmentation and acne. Vitamin C is commonly used to treat acne at 1-5%. However, when vitamin C is used as a raw material, its activity is easily lost over time, and when the vitamin C concentration is high, there are problems such as irritation and dryness. Here, we report that a vitamin C derivative, which is a vitamin C with a glycerol group and an octyl group, was used for acne treatment and had a good effect on acne treatment even at a low concentration.

Method: The subjects were 15 women aged 22 to 76 years. Before the start of use, 1 month and 2 months after the start of use, images were taken with a skin measuring device, and pores and porphyrin levels were analyzed. In addition, the degree of improvement was judged by two specialists of the Japan Society of Plastic and Reconstructive Surgery.

Results: 0.1% concentration preparation was used, and a good improvement effect was observed. Conclusion: This drug has good skin permeability, and it is easy to obtain the effect at a relatively low concentration. In addition, since the glycerol group may alleviate the feeling of dry skin due to the suppression of sebum secretion, which is a drawback of vitamin C lotion, it is easier to obtain the skin-beautifying effect of vitamin C. It is highly possible that this was exerted not only by the antioxidant and anti-inflammatory effects of vitamin C, but also by the antibacterial effect of the octyl group. In the future, we would like to examine the effects of pigmentation treatment and wrinkle treatment, and also examine the optimum concentration.

目的：近年来，为了治疗痤疮而拜访美容皮肤科医生的患者数量正在增加。在医疗保险中，诸如阿达帕林和纳地氟沙星等处方已经很普遍，不仅对治疗痤疮而且对改善痤疮和保持良好状态的兴趣日益浓厚。在美容皮肤病学中，根据症状，考虑与保险医疗，化学脱皮，局部激光治疗等无关，考虑类维生素A口服，与妇科的共同检查等。其中，维生素C洗剂往往是皮肤护理的首选，并积极推广给关心轻度痤疮和毛孔的患者。根据浓度，它可用于治疗炎症后色素沉着和痤疮。维生素C通常用于治疗1-5％的痤疮。然而，当将维生素C用作原料时，其活性随时间容易丧失，并且当维生素C浓度高时，存在刺激性和干燥性等问题。在这里，我们报道了维生素C衍生物，它是具有甘油基和辛基的维生素C，被用于痤疮治疗，即使在低浓度下也对痤疮具有良好的治疗效果。

方法：受试者为15名22岁至76岁的女性。开始使用前，开始使用后1个月和2个月，使用皮肤测量仪拍摄图像，并分析毛孔和卟啉水平。另外，改善程度由日本整形外科学会的两名专家评判。

结果：使用0.1％浓度的制剂，观察到良好的改善效果。

结论：该药具有良好的皮肤通透性，在较低浓度下很容易获得疗效。另外，由于甘油基团由于抑制皮脂分泌而减轻了皮肤干燥的感觉，这是维生素C乳液的缺点，因此更容易获得维生素C的美化皮肤的效果。这很可能不仅是由于维生素C的抗氧化和抗炎作用，而且还因为辛基的抗菌作用。将来，我们将研究色素沉着处理和皱纹处理的效果，并考虑最佳浓度。

2014

The 37th Annual Meeting of the Japanese Society of Aesthetic Surgery, Luncheon Seminar 6

"Functionality of novel vitamin C derivative GO-VC and its effect on acne and its inflammation" Date: September 4, 2014 (Thursday)

Place: Tokyo Dome Hotel

Chair: Professor Hitoshi Masaki, Photoaging Laboratory, Faculty of Applied Biology, Tokyo University of Technology

＜Lecture1>

Title: Functionality of a novel vitamin C derivative GO-VC and its effect on acne vulgaris and its inflammation

Presenter: Satsuki Osame (Osame Skin Clinic, Director)

Abstract: In recent years, glyceryl ascorbic acid has been developed as a novel vitamin C derivative. Glyceryl ascorbic acid is a combination of glycerin and ascorbic acid, and it has become possible not only to have a function but also to add ascorbic acid ester to a gel in a high concentration, which was difficult with APS and APM. We will present the effect of this glyceryl ascorbic acid (GO-VC) on acne.

摘要：近年来，甘油抗坏血酸已被开发为一种新型的维生素C衍生物。甘油抗坏血酸是甘油和抗坏血酸的组合，不仅具有功能，而且还可以向凝胶中高浓度添加抗坏血酸酯，这对于APS和APM是困难的。我们将介绍这种甘油基抗坏血酸（GO-VC）对痤疮的作用。

＜Lecture2＞

Title: Topical functional cosmetic ingredients and application to in-hospital preparations

Presenter: Takeshi Nagata (ITO Co., Ltd.)

Abstract: Active oxygen generated in cells by ultraviolet rays and the like is greatly involved in the onset of acne vulgaris. Vitamin C derivatives have a high effect of removing active oxygen, but their existing products have drawbacks such as low stability and promotion of dry skin. This time, we evaluated the effect of external application on the skin using a novel vitamin C derivative "GO-VC" that improved these points. As a result, the number and area of redness were reduced and a remarkable improvement effect on acne was observed, suggesting that it may have high effectiveness as a home care cosmetic ingredient.

摘要：紫外线等在细胞内产生的活性氧与寻常痤疮的发病有关。维生素C衍生物具有很高的去除活性氧的作用，但是它们现有的产品具有诸如稳定性低和促进皮肤干燥的缺点。这次，我们使用改善了这些问题的新型维生素C衍生物“ GO-VC”评估了外用剂对皮肤的影响。结果，减少了发红的数量和面积，并观察到了对痤疮的显着改善效果，表明它可能具有作为家庭护理化妆品成分的高功效。

Co-sponsored by: ITO Co., Ltd.

The 57th Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery

Date and time: April 11, 2014 (Friday) 12: 00-13: 00

Venue: Nagasaki Shimbun Culture Hall 5th Venue (Coral Room)

Theme: Functionality of tranexamic acid and novel vitamin C derivatives and their applications

Moderator: Professor Kazuo Kishi (Professor, Department of Plastic Surgery, Keio University School of Medicine)

Subject 1: Application of tranexamic acid with iontophoresis

-Effect of combined use with bio-cellulose mask sheet with high adhesion and moisture retention-

Speaker 1: Dr. Fumiko Mori (Director, Lifestyle Medical Center Clinic Mori) Subject 2: Functionality and In-Hospital Application of New Vitamin C Derivatives GO-VC presented by Takeshi Nagata (Senior Researcher, IT O Pro Vitamin Research Center Co., Ltd.)

The 113th Annual Meeting of the Japanese Dermatological Association

Date and time: May 31, 2014 (Saturday) 08:30 ~ 09:30

Venue: Kyoto International Conference Center 6th Venue (RoomE)

Theme: Skin permeability of vitamin C and its derivatives

What is Vitamin C Derivative Skin Permeability?

What are vitamin C derivatives applied in hospitals?

Everything is here now Chair:

Akira Kawada (Professor, Department of Dermatology, Kinki University School of Medicine) Subject 1: Skin Permeability of Chemicals and Its Prediction: Skin Permeability of Vitamin C and Its Derivatives

Speaker 1: Professor Kenji Sugibayashi (Professor, Department of Pharmaceutical and Cosmetic Dynamics Control, Faculty of Pharmaceutical Sciences, Josai University)

Subject 2: Functionality and In-Hospital Application of New Vitamin C Derivatives GO-VC Speaker 2: Takeshi Nagata (Senior Researcher, IT O Pro Vitamin Research Center Co., Ltd.)

2013

The 56th Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery

Date: April 4, 2013 at Keio Plaza Hotel

Chair: Professor Kazuo Kishi, Department of Plastic Surgery, Keio University School of Medicine

Theme: Basics and Clinical Practices of New Vitamin C Derivatives

-Skin Care Guidance for Spots, Wrinkles and Acne at Clinics-Using Vitamin C Derivatives-

Performer: Ayako Mori (Director, Lifestyle Medical Center Clinic Mori)

Abstract: The role of skin care guidance is very important not only in cosmetic dermatology but also in the field of plastic surgery and cosmetic surgery. If laser and surgery are used as "treatment," skin care is considered to complement medical care as "preventive medicine" and "maintenance." This time, we will introduce the clinical results of acne care using APMz and fullerene of ascorbyl phosphate M / Zn salt, and anti-wrinkle and anti-spot effects using vitamin C derivative nanocapsules "Nanosphere" as skin care to be instructed on a daily basis. In addition, as a treatment applying cosmetic materials, we prepared a bFGF preparation based on vitamin C derivative nanocapsules "Nanosphere" and investigated a safer bFGF dermis introduction method.

摘要：皮肤护理指导的作用不仅在美容皮肤病学中很重要，而且在整形外科和美容外科领域中也非常重要。如果将激光和外科手术用作“治疗”，则皮肤护理被认为是对医疗服务的补充，作为“预防药物”和“维护”。这次，我们将介绍使用APMz和抗坏血酸磷酸酯M / Zn盐的富勒烯进行痤疮护理的临床结果，以及使用维生素C衍生纳米胶囊“纳米球”作为皮肤护理的每日抗皱和抗斑点效果的日常指导基础。另外，作为使用美容材料的治疗方法，我们制备了基于维生素C衍生物纳米胶囊“ Nanosphere”的bFGF制剂，并研究了一种更安全的bFGF真皮导入方法。

Functionality of New Vitamin C Derivatives

Performer: Dr. Yukihiro Fujimoto (Director of Clinic F)

Abstract: In recent years, glyceryl ascorbic acid has been developed as a novel vitamin C derivative. Glyceryl ascorbic acid is a combination of glycerin and ascorbic acid, and it has become possible not only to have a function but also to add ascorbic acid ester to a gel in a high concentration, which was difficult with APS and APM. This paper describes the functionality of this glyceryl ascorbic acid.

摘要：近年来，甘油抗坏血酸已被开发为一种新型的维生素C衍生物。甘油抗坏血酸是甘油和抗坏血酸的组合，不仅具有功能，而且还可以向凝胶中高浓度添加抗坏血酸酯，这对于APS和APM是困难的。本文介绍了这种甘油基抗坏血酸的功能。

The 112th Annual Meeting of the Japanese Dermatological Association

Date : June 15, 2013 (Saturday) at Pacifico Yokohama

Chair: Professor Akira Kawada, Department of Dermatology, Faculty of Medicine, Kinki University

Theme: Unknown Functions of Vitamin C Derivatives

"Effects of Vitamin C and its derivatives on the skin"

Speaker: Dr. Hitoshi Masaki (Professor, Photoaging Laboratory, Faculty of Applied Biology, Tokyo University of Technology)

Abstract: Vitamin C (VC) is one of the most attractive vitamins in the fields of cosmetics and cosmetological skin. VC is a kind of water-soluble vitamin and is generally known as an antioxidant vitamin because it has a strong reducing power. It has been confirmed that the water distribution in the skin plays an important role in maintaining the homeostasis of the skin, and that changes in the state of the water distribution cause the production of inflammatory cytokines in the epidermis.

In addition, the homeostasis of the skin is impaired by the stimulation of the external environment, especially sunlight. Repeating such a condition leads to the formation of pigmented spots and wrinkles. It has been confirmed that VC has an action of promoting the synthesis of sphingolipid involved in the epidermal barrier function and an action of suppressing the production of inflammatory cytokines and chemokines derived from its antioxidant power. This paper describes the effects of VCs and VC derivatives on maintaining skin homeostasis.

摘要：维生素C（VC）是化妆品和美容皮肤领域中最有吸引力的维生素之一。 VC是一种水溶性维生素，由于具有很强的还原能力，因此通常被称为抗氧化剂维生素。已经证实，皮肤中的水分布在维持皮肤的体内平衡中起重要作用，并且水分布状态的变化引起表皮中炎性细胞因子的产生。另外，皮肤的动态平衡会受到外界环境（尤其是阳光）的刺激而受损。重复这种情况会导致形成色素斑和皱纹。已经证实，VC具有促进参与表皮屏障功能的鞘脂的合成的作用，并且具有抑制源自其抗氧化能力的炎性细胞因子和趋化因子的产生的作用。本文介绍了VC和VC衍生物对维持皮肤稳态的影响。

The 36th Annual Meeting of the Japanese Society of Aesthetic Surgery

Date: October 18, 2013 (Friday) at Tokyo International forum

Chair: Professor Hitoshi Masaki, Photoaging Laboratory, Faculty of Applied Biology, Tokyo University of Technology

Theme: Unknown work of vitamin C

"Effects of Vitamin C and its derivatives on the skin (Chairperson's special lecture)"

Speaker: Dr. Hitoshi Masaki (Professor, Photoaging Laboratory, Faculty of Applied Biology, Tokyo University of Technology)

"Functionality of novel vitamin C derivatives"

Performer: Dr. Yukihiro Fujimoto (Director of Clinic F)

Abstract: In recent years, glyceryl ascorbic acid has been developed as a novel vitamin C derivative. Glyceryl ascorbic acid is a combination of glycerin and ascorbic acid, and it has become possible not only to have a function but also to add ascorbic acid ester to a gel in a high concentration, which was difficult with APS and APM. This paper describes the functionality of this glyceryl ascorbic acid.

2012

The 55th Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery

Date : April 11, 2012 (Wednesday) at Hotel New Otani

Chair: Professor Kazuo Kishi, Department of Plastic Surgery, Keio University School of Medicine

Theme: New transdermal introduction method of bFGF and anti-wrinkle and anti-acne effect by new isoflavone

1.Examination of bFGF introduction method-various electrical introduction methods, combined introduction method with erbium yag fractional laser, and histopathological consideration bFGF therapy using various introduction methods

2. New cosmetic raw material fermented soybean germ extract-examination of effects by external use Mainly for anti-wrinkle effect and virilized acne

Performer: Ayako Mori (Director, Lifestyle Medical Center Clinic Mori)

Abstract: At last year's General Assembly, we reported that electroporation (electroporation) is cosmetically useful as an intradermal administration method of bFGF (Basic FGF), a human fibroblast growth factor that replaces injection therapy. Here we report the introduction of bFGF in combination with an erbium yag fractional laser and the macroscopic improvement effect of scar and aged skin. In addition, a basic experiment was added to investigate the change in the amount of macromolecular growth factor permeating into the skin over time in mouse skin. Furthermore, the induration site by bFGF injection therapy after one and a half years was examined histopathologically, and the treatment method was considered.

We also examined the effectiveness of fermented soybean germ extract (AglyMax) for external use. AglyMax has estrogen-like action, estrogen antagonism, antioxidant action, carcinogenesis suppression, adipocyte decomposition promoting action, immune action, blood pressure lowering action, blood flow improving action, and infertility improving action as oral functions. However, the effect of external use has not been confirmed at present. This time, we investigated the anti-wrinkle and anti-acne effects of the cream containing AglyMax.

摘要：在去年的大会上，我们报道了电穿孔（electroporation）在美容上可用作bFGF（基本FGF）的皮内给药方法，而bFGF是一种取代注射疗法的人成纤维细胞生长因子。在这里，我们报告结合FGFyag分数激光结合bFGF的引入以及疤痕和老化皮肤的宏观改善效果。

另外，添加了基础实验来研究随着时间的推移，渗透到皮肤中的大分子生长因子在小鼠皮肤中的变化。此外，对bFGF注射治疗一年半后的硬结部位进行了组织病理学检查，并考虑了治疗方法。我们还检查了发酵大豆胚芽提取物（AglyMax）外用的有效性。 AglyMax具有类似雌激素的作用，拮抗雌激素的作用，抗癌作用，抑制脂肪分解的促进作用，免疫作用，降低血压的作用，改善血流量和改善不育症的作用，但具有口服作用、目前尚未确认。这次，我们研究了含有AglyMax的面霜的抗皱和抗粉刺作用。

"What are the ingredients of the best-selling doctor's cosmetics now?"　

Speaker: Takeshi Nagata (Senior Researcher, IT O Pro Vitamin Research Center Co., Ltd.)

Abstract: Vitamin C derivatives such as ascorbic acid phosphate (APS, APM) and ascorbic acid palmitate 3Na (APPS) contained in the best-selling doctor cosmetics have high stability, especially APPS is parents. Because it is medium, it is extremely permeable to the skin, and when applied to the skin, it penetrates deep into the skin and is converted to vitamin C by various enzymes present in the skin, providing excellent antioxidant and anti-spot effects. , Wrinkle effect, etc. Introducing trend cosmetic raw materials such as peptides and nanocapsule raw materials that are blended in popular doctor cosmetics.

摘要：畅销医生化妆品中所含的维生素C衍生物，如抗坏血酸磷酸酯（APS，APM）和抗坏血酸棕榈酸酯3Na（APPS）具有很高的稳定性，尤其是APPS是母体，因为它是中等的，所以对人体的渗透性极强。在皮肤上使用时，它渗透到皮肤深处，并通过皮肤中存在的各种酶转化为维生素C，具有出色的抗氧化和抗斑点效果，抗皱作用等。介绍流行的医生化妆品中掺入的趋势化妆品原料，例如肽和纳米胶囊原料。

The 111th Annual Meeting of the Japanese Dermatological Association

Date: June 1, 2012 (Friday) at Kyoto International Conference Center

Chair: Professor Akira Kawada, Department of Dermatology, Faculty of Medicine, Kinki University　

Theme: Ascorbic acid derivatives and collagen synthesis

"In vivo Gelatin: Collagen Biosynthesis Research Using Vitamin C Stabilizing Derivatives"

Speaker: Professor Yasutada Imamura (Professor, Department of Applied Chemistry, Faculty of Engineering, Kogakuin University)

Abstract: Vitamin C is required for the formation of the three-helical structure of collagen. When vitamin C is deficient, the three-helical structure is not stably formed and is not secreted from the cell but decomposed inside the cell. In this way, the quality control mechanism of the molecular structure is assumed for collagen. However, it was shown that in type IV collagen, which is basement membrane collagen, a polypeptide chain having no three-helical structure is secreted extracellularly. Gelatin whose collagen structure is destroyed by heat treatment or the like is called gelatin, and it has been considered that gelatin does not exist in the living body because it is easily decomposed by protease. However, it was shown that a single-strand polypeptide chain having the same amino acid sequence as type IV collagen but not having a three-helical structure can exist in the living body. In this seminar, we will summarize the action of vitamin C in collagen biosynthesis and introduce our findings on the biosynthesis of gelatin in vivo and its physiological role.

摘要：维生素C是胶原蛋白三螺旋结构形成所必需的。当维生素C不足时，三螺旋结构不能稳定地形成，因此它不会从细胞中分泌出来并在细胞内分解。以此方式，假定了胶原蛋白的分子结构的质量控制机制。但是，显示出在IV型胶原（即基膜胶原）中，在细胞外分泌不具有三螺旋结构的多肽链。通过热处理等破坏了胶原结构的明胶被称为明胶，人们认为明胶由于不易被蛋白酶分解而在生物体内不存在。然而，已表明在活体内可以存在具有与IV型胶原相同的氨基酸序列但不具有三螺旋结构的单链多肽链。在本研讨会中，我们将总结维生素C在胶原蛋白生物合成中的作用，并介绍我们在明胶体内生物合成及其生理作用方面的发现。

2011

Seminar related to FGF electroporation

Date: August 21, 2011 (Sunday) at Uraku Aoyama 2F (Tokyo)

A luncheon seminar entitled "Intradermal introduction method by electroporation of bFGF and stability of FGF by nanospheres" will be held on the following schedule. For details, please contact the MBF Aoyama Seminar below.

Organized by: Japan Society for Anti-Aging Cosmetic Medicine, MBF Aoyama Seminar http://mbf-new.com/mbf/

Cooperated by : ITO Co., Ltd. ]

Speaker: Dr. Ayako Mori (Director of Clinic Mori, Doctor of Medicine, Part-time Doctor of Plastic Surgery, Keio University School of Medicine Medical Skin Care Outpatient Doctor)

The 54th Japan Society of Plastic and Reconstructive Surgery / Academic Meeting Luncheon Seminar

Date : April 13, 2011 (Wednesday) at Hotel Clement Tokushima

Chair: Professor Kazuo Kishi, Department of Plastic Surgery, Keio University Hospital

Theme: Application of cosmetic ingredients to the beauty field-Focusing on FGF introduction methods-

"BFGF therapy using various induction methods"

Presenter: Ayako Mori (Director, Lifestyle Medical Center Clinic Mori)

Abstract: Various administration methods have been investigated for skin rejuvenation using the skin ulcer therapeutic agent Fiblast R (hereinafter referred to as bFGF). Although there are reports that administration is performed by subcutaneous injection, bFGF preparations are external preparations, and injection administration is not permitted at this time. We have obtained good results by administration by electroporation and ultrasonic iontophoresis without injection in cases for scar morphology improvement and skin rejuvenation, but we also administered by microneedle sheet. The usefulness was examined. Microneedle is a sheet in which extremely small needles made mainly of hyaluronic acid are lined up. When attached to the skin, the microneedles dissolve in the intradermal water, and the content components elute into the skin to break through the stratum corneum and deliver the active ingredients into the epidermis or dermis. The length of the needle can also be adjusted, and delivery from the stratum corneum to the inside of the dermis can be performed depending on the length. This time, using microneedle containing bFGF preparation and microneedle containing only hyaluronic acid, the effect of improving facial wrinkles was examined using a skin image analyzer Visia, and electroporation, ultrasonic iontophoresis and their usefulness were compared. I will report it.

摘要：已经研究了使用皮肤溃疡治疗剂Fiblast R（以下称为bFGF）进行皮肤修复的各种给药方法。尽管有报道称通过皮下注射进行给药，但是bFGF制剂是外用制剂，此时不允许注射给药。通过电穿孔和超声离子电渗疗法在不改善疤痕形态和恢复皮肤活力的情况下进行注射，取得了良好的效果，但我们也通过微针片进行了研究，并检查了其有效性。微针是将主要由透明质酸制成的极小的针排列在一起的薄片。当附着在皮肤上时，微针溶解在皮内水中，并且含量成分被洗脱到皮肤中以穿透角质层并将活性成分输送到表皮或真皮中。还可以调节针的长度，并且可以根据长度来执行从角质层到真皮内部的递送。这次，使用含bFGF制剂的微针和仅含透明质酸的微针，使用皮肤图像分析仪Visia检查了改善面部皱纹的效果，并比较了电穿孔，超声离子电渗疗法及其有用性，我将进行报告。

"What are the ingredients of the best-selling doctor's cosmetics now?"

Presenter: Takeshi Nagata (Senior Researcher, IT O Pro Vitamin Research Center Co., Ltd.)

Abstract: Spots and wrinkles that are a problem for women's skin. It is a well-known fact that ultraviolet rays (UV) are involved in these formations, and in particular, collagen (collagen fibers) and elastin in the dermal extracellular matrix, which are deeply involved in the production of melanin, which is the main body of stains, and the formation of wrinkles. It cannot be denied that UV may be deeply involved in the quantitative and qualitative changes of (elastic fibers) and glycosaminoglycans (GAG). Vitamin C is expected to have anti-spot and wrinkle effects because its antioxidant action may suppress all oxidative reactions involved in melanin synthesis and is essential for collagen production. However, since vitamin C itself is extremely unstable, it may be converted into vitamin C radicals by UV or the like, which may adversely affect the skin such as irritation. Vitamin C derivatives such as ascorbic acid phosphate (APS, APM) and ascorbyl palmitate 3Na (APPS), which are contained in popular doctor cosmetics, have overcome this drawback. These have high stability, especially APPS is parenteral, so it has very high skin permeability, and when applied to the skin, it penetrates deep into the dermis and exists in the skin. It is converted to vitamin C by various enzymes and exerts excellent antioxidant action, anti-spot effect, wrinkle effect and the like. We are planning to introduce trend cosmetic raw materials such as peptides and nanocapsule raw materials that are blended in popular doctor cosmetics.

摘要：斑点和皱纹是女性皮肤的问题。众所周知的事实是，紫外线（UV）参与了这些形成过程，特别是真皮细胞外基质中的胶原蛋白（胶原纤维）和弹性蛋白，它们深深参与了黑色素的产生，而黑色素是主要的污渍和皱纹的形成是不可否认的，紫外线可能会深深地参与（弹性纤维）和糖胺聚糖（GAG）的数量和质量变化。预计维生素C具有抗斑点和皱纹的作用，因为其抗氧化作用可以抑制黑色素合成中涉及的所有氧化反应，并且对胶原蛋白的生产至关重要。但是，由于维生素C本身非常不稳定，因此可能被紫外线等转化为维生素C自由基，这可能对皮肤产生不利影响，例如刺激皮肤。流行的医生化妆品中所含的维生素C衍生物，例如抗坏血酸磷酸酯（APS，APM）和抗坏血酸棕榈酸酯3Na（APPS），已经克服了这一缺点。它们具有很高的稳定性，尤其是APPS肠胃外，因此具有很高的皮肤渗透性，并在皮肤上渗透到真皮深处并存在于皮肤中，可通过多种酶转化为维生素C，并具有出色的抗氧化性作用，抗斑点作用，皱纹作用等。我们计划引入流行的化妆品原料，例如掺入流行的医生化妆品中的肽和纳米胶囊原料。

The 110th Annual Meeting of the Japanese Dermatological Association Morning Seminar Canceled due to the earthquake

Date: April 16, 2011 (Saturday) at Pacifico Yokohama

Chair: Professor Akira Kawada, Department of Dermatology, Faculty of Medicine, Kinki University

Theme: Application of cosmetic ingredients to the beauty field

"Control of cell proliferation and function by active-sustaining vitamin C"

by Ryuichiro Hata (Professor, Center for Intractable Oral Diseases, Kanagawa Dental University)

Abstract: Vitamin C is essential as a cofactor for the hydroxylase of proline residue and lysine residue required for the maturation process in the synthesis process of collagen, which is a major component of skin, bone, tendon and the like. When we add ascorbic acid phosphate (Asc2-P, active-sustaining vitamin C) to the culture system of skin fibroblasts, liver cells, and osteoblasts, it activates cell proliferation, extracellular matrix metabolism, and is released. We found that three-dimensional tissues and organs can be regenerated from cells. Asc2-P promotes ECM maturation by activating the synthesis of collagen that forms the backbone of extracellular matrix (ECM). The formed ECM forms a microenvironment around the cell and gives the cell three-dimensional three-dimensional structure information to promote organ formation. In this talk, we will discuss various actions that cannot be explained by the conventional cofactor action of vitamin C, such as the recent anticancer action and antiviral action of vitamin C, as well as the action of Asc2-P in organogenesis.

摘要: 维生素C是胶原合成过程中成熟过程必需的脯氨酸残基和赖氨酸残基羟化酶的辅助因子，胶原是皮肤，骨骼，肌腱等的主要成分。当我们在皮肤成纤维细胞，肝细胞和成骨细胞的培养系统中加入抗坏血酸磷酸酯（Asc2-P，能维持生命的维生素C）时，它会激活细胞增殖，细胞外基质代谢并被释放，我们发现这是三维的组织和器官可以从细胞再生。Asc2-P通过激活形成细胞外基质（ECM）骨架的胶原蛋白的合成来促进ECM成熟。形成的ECM在细胞周围形成微环境，并赋予细胞三维三维结构信息以促进器官形成。在本次演讲中，我们将讨论无法用维生素C的常规辅助因子作用解释的各种作用，例如维生素C的近期抗癌作用和抗病毒作用，以及Asc2-P在器官发生中的作用。

2010

The 109th Annual Meeting of the Japanese Dermatological Association Luncheon Seminar

Date: April 17, 2010(Saturday) at RIHGA Royal Hotel Osaka

Chair: Professor Akira Kawada, Department of Dermatology, Faculty of Medicine, Kinki University

Theme: Application of cosmetic ingredients to the beauty field-Exploring new possibilities-

"Application of regenerative medicine to cosmetology dermatology" by

Professor Hirohiko Akamatsu (Professor, Department of Applied Cell Regenerative Medicine, Fujita Health University School of Medicine)

Abstract: Regenerative medicine is a treatment method in which stem cells or cells that have been induced to differentiate from stem cells into therapeutic cells are transplanted into the tissue to be regenerated, and the function of that tissue is fundamentally repaired and regenerated. It is highly expected as a dream medical treatment that can deal with diseases that were difficult to treat. Currently, stem cells are classified into several types such as embryonic stem cells (ES cells), somatic stem cells, and induced pluripotent stem cells (iPS cells), and application research for each stem cell to regenerative medicine is being conducted. It is being advanced. In this lecture, I would like to introduce some of the research results of the performers on somatic stem cells in the epidermis, dermis and panniculus adipos, and mention the possibility of applying regenerative medicine to cosmetic dermatology.

摘要: 再生医学是将干细胞或已被诱导从干细胞分化为治疗细胞的细胞移植到组织中进行再生的方法，该组织的功能从根本上得到了修复和再生。有望作为可以治疗难以治疗的疾病的理想医疗方法。目前，将干细胞分为胚胎干细胞（ES细胞），体细胞干细胞和诱导多能干细胞（iPS细胞）等几种类型，并且每种干细胞在再生医学中的应用研究正在进行中。先进的。在本讲座中，我想介绍表演者对表皮，真皮和脂肪团中的体干细胞的一些研究成果，并提到将再生医学应用于美容皮肤病学的可能性。

"Synthetic peptide for high-performance anti-aging" by

Dr.VolkerRosenberger（DSMNutritionalProductsLtd）

Abstract: Protein controls all important processes in the skin. It is involved in the suppression or promotion of specific functions in which proteins are bound to each other, such as keys and keyholes. When these proteins are applied to cosmetics, they do not penetrate to the target due to their large molecular weight, which hinders their action. The key-keyhole relationship involves a small peptide region in the protein. By combining amino acids, it becomes possible to synthesize peptides in key parts of proteins and lock receptors. The peptides synthesized in this way exert a function of regulating a specific protein. We have various peptides that have functions such as promoting muscle relaxation like wagrelin-1 present in snake venom, promoting collagen synthesis like thrombospondin 1, and promoting the synthesis of hemidesmosole-type proteins. By synthesizing and applying it to the skin, the permeability to the skin was enhanced and useful results were obtained.

摘要：蛋白质控制着皮肤中的所有重要过程。它参与抑制或促进蛋白质彼此结合的特定功能，例如键和锁孔。当这些蛋白质应用于化妆品时，由于分子量大，它们不会渗透到靶标中，从而阻碍了它们的作用。钥匙-钥匙孔关系涉及蛋白质中的小肽区域。通过结合氨基酸，有可能在蛋白质和锁定受体的关键部位合成肽。以这种方式合成的肽具有调节特定蛋白质的功能。我们拥有各种肽，这些肽具有促进肌肉松弛（如蛇毒中的wagrelin-1），促进胶原蛋白（如血小板反应蛋白1）的合成以及促进hemidesmosole型蛋白质的合成的功能。皮肤得到改善，并获得了有用的结果。

‘’About functional peptide raw materials for cosmetics’’ by

Shinobu Ito (Keio University Faculty of Pharmacy, Department of Drug Discovery Physics and Chemistry, CEO of ITO Co., Ltd.)

Abstract: In recent years, skin cell proliferation-promoting factors such as gloss factor patches and sprays have begun to be approved as wound healing drugs for the treatment of pressure ulcers and skin ulcers. Cosmetic manufacturers around the world are also focusing on the development of peptide raw materials for cosmetics, and many have been reported to have growth factor and hormone-like effects. Expected fields of peptide raw materials for cosmetics include spots, wrinkles, textures, tarmi, hair growth, acne, pores, UV care, etc., but cosmetics containing peptide raw materials have already begun to be put on the market. Unlike overseas, in Japan, due to the restrictions of the Pharmaceutical Affairs Law, there is a problem that raw materials registered as pharmaceutical raw materials cannot be used in cosmetics without special permission. In addition, there are restrictions on advertising, and there is a lack of information on peptide raw materials for cosmetics. This time, we will introduce cosmetic raw materials that are attracting attention as peptides that mainly have a growth factor-like action.

摘要: 近年来，皮肤细胞增殖促进因子如光泽因子贴剂和喷雾剂已被批准作为伤口愈合药物，用于治疗压疮和皮肤溃疡。全世界的化妆品制造商也都在关注化妆品用肽原料的开发，据报道许多都具有生长因子和类激素的作用。用于化妆品的肽原料的预期领域包括斑点，皱纹，质地，柏油，头发生长，粉刺，毛孔，紫外线护理等，但是含有肽原料的化妆品已经开始投放市场。与海外不同，在日本，由于受《药品事务法》的限制，存在一个问题，即未经特殊许可，注册为药品原料的原料不能用于化妆品。另外，对广告有限制，并且缺乏关于化妆品的肽原料的信息。这次，我们将介绍吸引人们注意的化妆品原料，主要是具有类似生长因子作用的肽。

The 53rd Japan Society of Plastic and Reconstructive Surgery / Academic Meeting Luncheon Seminar

Date: April 7, 2010 (Wednesday) at ANA Crown Plaza Hotel Kanazawa

Chair: Professor Emeritus, Department of Plastic Surgery, Keio University Hospital Professor Tatsuo Nakajima

Theme: Application of cosmetic ingredients to the beauty field

"Evaluation of the latest peptide cosmetic ingredients" by

Ayako Mori (Director, Lifestyle Medical Center Clinic Mori)

"About the latest peptide cosmetic ingredients" by

Shinobu Ito (Keio University Faculty of Pharmacy, Department of Drug Discovery and Physics and Chemistry, CEO of ITO Co., Ltd.)

The 62nd Annual Meeting of the Japanese Society of Obstetrics and Gynecology

Date: April 25, 2010 (Sunday) Luncheon Seminar (Venue: Tokyo International Forum)

Chair: Professor Isaka, Tokyo Medical University, Department of Obstetrics and Gynecology

"Evaluation of the latest growth factor (GF) cosmetic ingredients" by

Kiyoaki Tsutsumi (Director, Department of Plastic Surgery, Nagai Clinic)

"About the latest growth factor (GF) cosmetic ingredients" by Hajime Ito (ITO Co., Ltd.)

The 31st Annual Meeting of the Japanese Laser Medical Society

Luncheon Seminar

Date : November 14, 2010 at Wink Aichi Large Hall 2f

Moderator: Professor Kenji Yoshida, Department of Oral Surgery, Faculty of Dentistry, Aichi Gakuin University

Lecturer: Norio Daikusono, Nanocare Inc.

‘’USA latest world fastest 7 minutes dental whitening based on LED photochemistry’’

Lecturer: Takeshi Nagata Co., Ltd. ITO

‘’What are the ingredients of the best-selling doctor's cosmetics?

The 52nd Japan Society of Plastic and Reconstructive Surgery Luncheon Seminar

Date: April 24, 2009 (Friday) at Pacifico Yokohama Congress Centre

Chair: Professor Tatsuo Nakajima (Professor of Plastic Surgery, Keio University Hospital)

Theme: Functions and applications of amphipathic vitamins

"Stain treatment protocol that suppresses inflammation with nanomic tretinoin preparations" by

Dr. Ayako Mori (Director, Lifestyle Medical Center Clinic Mori)

"Functions of amphipathic vitamin E (TPNa)" by

Professor Eiichi Kitaguni (Showa Denko KK, Chemicals Division, Special Chemicals Department, Ph.D.)

"About the permeability of amphipathic vitamins to the skin" by Shinobu Ito (CEO of ITO)

The 108th Annual Meeting of the Japanese Dermatological Association

Date : April 25, 2009 (Saturday) Luncheon Seminar (Venue: Fukuoka Sun Palace Hotel)

Chair: Akira Kawada (Professor of Dermatology, Kinki University School of Medicine)

Theme: Application of new vitamin E derivatives to cosmetics

"Latest trends in antioxidant vitamins expected as external ingredients"

Speaker name: Professor Jiro Takada (Professor, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University)

Abstract: Vitamin E is classified into eight types according to the difference in chemical structure, and one of the ones that has been attracting attention in recent years is γ-tocopherol (γ-Toc). γ-Toc is abundant in foods such as nuts as a natural product. Originally, vitamin E is α-tocopherol, but recent studies have reported interesting benefits to γ-Toc. Contrary to the past evaluation that "γ-Toc is not important vitamin E", the paradigm shift of vitamin E by γ-Toc is occurring. Originally, γ-Toc has strong antioxidant properties, so it is easily oxidized by air and difficult to formulate. However, in our laboratory, γ-tocopheryl dimethylglycine (γ-TDMG), which is a derivative that can be efficiently supplied to the skin. Was developed. The water-soluble vitamin E derivative γ-TDMG is a vitamin E derivative that is not sticky, has a good feel, and can be efficiently converted to γ-Toc in the skin to exert a useful pharmacological effect.

摘要: 维生素E根据化学结构的不同可分为八种类型，近年来一直引起人们关注的一种是γ-生育酚（γ-Toc）。 γ-Toc在作为天然产物的坚果等食物中含量丰富。最初，维生素E是α-生育酚，但最近的研究报道了γ-Toc的有趣益处。与以往的“γ-Toc不是重要的维生素E”的评价相反，正在发生由γ-Toc引起的维生素E的范式转变。最初，γ-Toc具有很强的抗氧化性能，因此很容易被空气氧化并且难以配制，但是在我们的实验室中，γ-生育酚二甲基甘氨酸（γ-TDMG）是可以有效提供给皮肤的衍生物。被开发了。水溶性维生素E衍生物γ-TDMG是不粘性的，具有良好的手感并且可以在皮肤中有效地转化为γ-Toc以发挥有用的药理作用的维生素E衍生物。

"Correlation between the antioxidant activity of a novel water-soluble vitamin E derivative (TPNa) and the restoration of skin barrier function" by Dr. Eiichi Kitaguni (Dr. Pharmacy, Special Chemicals Department, Chemicals Division, Showa Denko KK)

Abstract: "TPNa: Vitamin E Sodium Phosphate" (main component of quasi-drugs) is substantially the world's first water-soluble vitamin E. While conventional vitamin E derivatives are oil-soluble, TPNa has acquired water solubility by introducing a phosphate group, resulting in improved transdermal absorbability and can be incorporated into lotions and beauty essences. became. TPNa quickly penetrates into the skin and is gently converted to vitamin E by the action of phosphatase in the skin, but when exogenous stress such as ultraviolet rays is applied, enzyme activity is enhanced and conversion is accelerated. "On-demand effect" can be expected. As the antioxidant action of TPNa, it has been confirmed that the removal of active oxygen suppresses lipid peroxide and the anti-inflammatory action, and further enhances tight junctions between epidermal cells and intercellular qualities (ceramide). TPNa can fundamentally improve skin troubles by strengthening the barrier function of the skin. In the 4-week monitor test, all monitors showed significant improvement.

摘要：“ TPNa：维生素E磷酸钠”（准药物的主要成分）实质上是世界上第一种水溶性维生素E。尽管常规的维生素E衍生物是油溶性的，但TPNa通过引入磷酸基团而获得了水溶性，从而改善了透皮吸收能力，并且可以掺入乳液和美容香精中。TPNa可以迅速渗透到皮肤中，并通过磷酸酶在皮肤中缓慢转化为维生素E，但是当施加紫外线等外源胁迫时，酶的活性会增强并加速转化，可以实现“按需效应”。预期的。作为TPNa的抗氧化作用，已证实去除活性氧可抑制脂质过氧化物和抗炎作用，并进一步增强表皮细胞与细胞间质（神经酰胺）之间的紧密连接。 TPNa可以通过增强皮肤的屏障功能从根本上改善皮肤问题。在为期4周的监控程序测试中，所有监控程序均显示出显着改善。

"Topical preparations of novel vitamin derivatives" by Shinobu Ito (ITO Co., Ltd., Keio University Faculty of Pharmacy, Pharmaceutical Discovery and Physical Chemistry)

Abstract: New vitamin derivatives have been developed one after another in recent years, but it is not surprisingly known how to prepare them as external preparations. Basics when using vitamin derivatives as cosmetic raw materials, such as stability and pH problems of each derivative in aqueous solution, problems of high-concentration vitamin C preparations, ion state of derivative molecules and selection of electrodes at the time of introduction, etc. Provide a topic.

摘要：近年来，新的维生素衍生物相继被开发出来，但是如何将它们作为外用制剂制备并不令人惊讶。使用维生素衍生物作为化妆品原料的基础，例如水溶液中每种衍生物的稳定性和pH问题，高浓度维生素C制剂问题，衍生物分子的离子状态以及引入时电极的选择等。提供一个话题。

2008

The 107th Annual Meeting of the Japanese Dermatological Association

Date: April 19, 2008 (Saturday) (Venue: Kyoto International Conference Center)

Chair: Akira Kawada (Professor, Department of Dermatology, Kinki University School of Medicine)

Theme: Cutting edge of moisturizing care ingredients

"Atopy and Imyu System Vance" by

Chie Kawachi (Kagawa University School of Medicine Integrated Immunosystems Donation Course Associate Professor Doctor of Engineering)

Abstract: Recent immunological studies have pushed the role of phagocytes in the immune system from one soldier to a general. It is becoming clear that phagocytes issue commands to control the entire immune system. The role of skin Langerhans cells is also important for atopic dermatitis, which has become a social problem, and we will introduce a part of the latest research report. In our laboratory, we isolated the immune balance substance LPS from special cells and confirmed its effect from the shipment that the role of phagocytic cells in these skins could be useful for the treatment of atopy. In the future, LPS may be effective for various immune diseases, and we will introduce the possibility.

摘要：最近的免疫学研究已将吞噬细胞在免疫系统中的作用从一名士兵推向了普通士兵。吞噬细胞发出命令来控制整个免疫系统已经变得越来越清楚。皮肤朗格汉斯细胞的作用对于已成为社会问题的特应性皮炎也很重要，我们将介绍最新研究报告的一部分。在我们的实验室中，我们从特殊细胞中分离了免疫平衡物质LPS，并从运送中证实了其作用，即吞噬细胞在这些皮肤中的作用可能对特应性疾病的治疗有用。将来，脂多糖可能对多种免疫疾病有效，我们将介绍这种可能性。

"Latest moisturizing skin care useful for clinical use" by

Mr. Daisuke Seki (Doctor of Medicine, Seki Dermatology Clinic)

Abstract: Due to various factors in modern society, there are many skin diseases based on dry skin such as atopic dermatitis and senile xeroderma. In the treatment of these dry skin diseases, the quality of skin care at home greatly affects the therapeutic effect. Introducing the latest ingredients and their effects among the important elements for moisturizing care such as sebaceous membrane, natural moisturizing factor, and intercellular lipids in the keratinocytes.

摘要：由于现代社会的各种因素，基于干性皮肤的皮肤疾病很多，如特应性皮炎和老年性干性皮肤病。在治疗这些干性皮肤病中，在家中的皮肤护理质量极大地影响了治疗效果。在保湿护理的重要元素（例如皮脂膜，天然保湿因子和角质形成细胞中的细胞间脂质）中引入最新成分及其作用。

"Alternative Complementary Therapy and Atopy" by Aki Shuuhei teacher (Doctor of Philosophy, Institute of Fuji Sangyo Co., Ltd.)

‘’Atopic disease is one of the major diseases targeted by alternative complementary therapy.’’

Abstract: Until now, various alternative complementary therapies have been used, but many of them are not satisfied with their effects. In the past, we have been conducting research on vitamin B1 deficiency that occurs in farmed fish in the field of vitamin B derivatives derived from garlic and have been developing products. The action and the effect on atopy were recognized. Here, we report on the applied research of the ingredients in the field of cosmetics (especially bath salts).

摘要：到目前为止，已经使用了各种替代性补充疗法，但其中许多人对其效果并不满意。过去，我们一直在研究大蒜中的维生素B衍生物领域中养殖鱼类中出现的维生素B1缺乏症，并且一直在开发产品，人们认识到其作用和对特应性的影响。在这里，我们报告了化妆品成分（特别是沐浴盐）在成分中的应用研究。

Japan Society of Plastic and Reconstructive Surgery General Assembly Luncheon Seminar

Date: April 9, 2008 (Wednesday) at Nagoya Congress Center

Chair: Chairman of NPO Cranio Facial Center Professor Emeritus of Kinki University Professor Hiroshi Ueishi

"About tranexamic acid-containing nanocapsules" by

Dr. Yoichi Terashima, Director of Avenue Roppongi Clinic

"About retinoic acid-containing nanocapsules" by

Dr. Ayako Mori, Director of Lifestyle Medical Center Knick Mori

"Focusing on growth factor activators" by

Dr. Takao Nose, Director of Skin Clinic Nose

2007

The 106th Japanese Dermatological Association General Assembly Luncheon Seminar

Date: April 22, 2007 (Sunday) at Pacifico Yokohama

Theme: Development of new whitening agent and suppression of late melanin production

Chair: Masako Mizoguchi (Professor Emeritus, St. Marianna University School of Medicine)

‘’To suppress melanin production in the whole process by developing a melanin monomer scavenger " by Dr. Yutaka Mishima (Mishima Dermatology Research Institute)

Abstract: Many current whitening agents utilize suppression of tyrosinease, which regulates the initial melanin production pathway (DOPAquinone rather than tyrosine). On the other hand, the subsequent progression from DOPAchrome to melanin polymer via two melanin monomers (DHICA, DHI) and the regulation by DOPAchromet automerase, DHICA oxidase, etc. were elucidated. Future whitening agents should aim to suppress melanin production in the entire early and late stages. We developed early process-suppressing kojic acid (KA) in 1988, but newly discovered BPA that traps both DHICA and DHI and pheomelanin intermediate (5SCD) as compounds that suppress late-stage processes. After various safety tests, a volunteer test of the fair-skinned effect of BPA cream on UV-induced pigmentation was conducted, and a remarkable therapeutic effect on pigmentation such as chloasma was obtained in combination with KA. Report including future prospects.

摘要：目前许多美白剂都利用酪氨酸酶的抑制作用来调节最初的黑色素生成途径（DOPA醌而不是酪氨酸）。另一方面，阐明了随后通过两个黑色素单体（DHICA，DHI）从DOPAchrome转变为黑色素聚合物的过程，并阐明了DOPAchromet自聚酶，DHICA氧化酶等的调控作用。

未来的增白剂应旨在在整个早期和晚期抑制黑色素的产生。 1988年，我们开发了抑制早期过程的曲酸（KA），但新发现的BPA既可以捕集DHICA和DHI，也可以捕集苯丙氨酸甲酯中间体（5SCD）作为抑制后期过程的化合物。经过各种安全性测试后，对BPA乳霜对UV引起的色素沉着的皮肤白化效果进行了自愿测试，当与KA组合使用时，获得了对色素沉着如黄褐斑的显着治疗效果。报告包括未来前景。

"How to control melanogenesis? From a chemist's point of view" by

Professor Kazumasa Wakamatsu (Fujita Health University Faculty of Health Sciences Trace Component Analysis)

Abstract: Melanin consists of black-black-brown, insoluble eumelanin and reddish-brown-yellow, alkali-soluble pheomelanin. There are many unclear points about the structure of melanin, but eumelanin is 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA), while pheomelanin is cysteinyldopa ( It is a polymer in which an oxidative polymer of 5SCD) is complicatedly bonded. Our interest is in how to control melanogenesis. As part of this, attention was focused on 1) inhibition of tyrosinase, TRP1 and TRP2, which are key enzymes of melanogenesis, 2) regulation of MC1R activity, and 3) interaction between melanosomes maturation and migration. On the other hand, in recent years, Mishima et al. Have produced a new idea of suppressing further oxidative polymerization by a complex formation reaction utilizing the properties of the catechol skeleton possessed by DHI and DHICA, which are precursors of eumelanin, and have achieved results. We describe how melanogenesis is controlled, including the latest research results.

摘要：黑色素由黑色-黑色-棕色的不溶性Eumelanin和红色-棕色-黄色的碱溶性酞菁组成。关于黑色素的结构有很多不清楚的地方，但黑色素是5,6-二羟基吲哚（DHI）和5,6-二羟基吲哚-2-羧酸（DHICA），而色欧米宁是半胱氨酰多巴（一种在其中氧化的聚合物5SCD的聚合物）的键很复杂。我们的兴趣在于如何控制黑色素生成。作为此过程的一部分，注意力集中在1）抑制酪氨酸酶，TRP1和TRP2（它们是黑色素生成的关键酶），2）调节MC1R活性以及3）黑素体成熟与迁移之间的相互作用上。另一方面，近年来，三岛等人提出了一种新的想法，即通过利用DHI和DHICA的邻苯二酚骨架的特性（是Eumelanin的前体），通过复杂的形成反应来抑制进一步的氧化聚合反应，以及取得了成绩。我们描述了如何控制黑色素生成，包括最新的研究结果。

Whitening treatment in "Women's outpatient cosmetology skin specialty" by

Dr. Akira Kawada, Dr. Natsuko Konishi (Department of Dermatology, Kinki University School of Medicine)

Abstract: In recent years, cosmetic skin treatments have diversified into laser, phototherapy, chemical peels, and various external preparations, and doctors have a wide range of choices. Introducing recent treatment methods for "whitening", which is of particular interest to women in beauty, as well as the content of "whitening" treatments performed by "Women's Outpatient Cosmetology Skin Specialization". In addition, it has recently been reported that fullerenes eliminate free radicals derived from UVB, and biotin also has a whitening effect. The latest redoxes such as fullerenes, biotins, and antioxidant vitamin derivatives (APPS, TPNa) Whitening agents containing molecular derivatives are also introduced. We will also report on the results of these whitening agents tested by the "Women's Outpatient Cosmetology Skin Specialty".

摘要:近年来，皮肤美容治疗已广泛应用于激光，光疗，化学换肤和各种外用制剂，医生的选择范围很广。除了介绍美颜女性特别感兴趣的最新“美白”治疗方法外，我们还将介绍“妇女门诊美容皮肤专业化”所进行的“美白”治疗的内容。另外，最近有报道说，富勒烯对生物素具有增白作用，并具有清除来自UVB的自由基的作用，还引入了含有分子衍生物的增白剂。我们还报告了由“妇女门诊美容皮肤科”测试的这些增白剂的结果。

The 50th Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery

Chair: Professor Hiroshi Ueishi (Professor, Department of Plastic Surgery, Kinki University School of Medicine)

Theme: Science of beautiful skin. The possibilities and limits of supplements and cosmetics.

‘’What do doctors expect from supplements?’’ by

Dr. Shigeki Inui (Osaka University Graduate School of Medicine, Department of Dermatology and Hair Regeneration Medicine, Associate Professor, Department of Dermatology, Faculty of Medicine Hospital)

‘’Can doctors make effective use of supplements and cosmetics?’’ by

Ayako Mori (Director of Clinic Mori)

‘’An example of cosmetic ingredient development’’ by Dr. Eiichi Kitaguni Showa Denko KK

2006

The 105th Annual Meeting of the Japanese Dermatological Association Luncheon Seminar

Date: June 3, 2006 at Kyoto International Conference Center

Chair: Akira Kawada (Professor, Department of Dermatology, Kinki University School of Medicine)

‘’Importance of UV protection in younger age groups and UV protection methods’’ by

Dr. Masamitsu Ichihashi (Director of Sun Clinic)

Abstract: Photoaging is caused by solar UV exposure from childhood as a decisive factor. As measures against UV rays from childhood, (1) teach children the effects of solar UV rays on humans, (2) use shade to avoid strong sunburn, and implement Slip, Slop, Slap. In particular, it is important to learn the habit of using sunscreen in childhood. I would like to recommend a sunscreen with SPF of 10 to 15, PA ++, which is less irritating to the skin and is not absorbed by the skin when going to kindergarten or school. Also, during summer outdoor sports and leisure activities where you are exposed to strong solar UV rays for a long time, please use SPF30 or higher and PA +++ and enjoy yourself without worrying about sunburn. After the age of 20, as photoaging progresses, topical antioxidants and supplements are added as anti-oxidant and anti-inflammatory measures. When today's children join the ranks of the elderly, I want them to contribute brightly and actively to society with their youthful skin aged 30-40.

摘要：光老化是由童年时期的太阳紫外线照射引起的，这是决定性因素。作为防止儿童时期的紫外线的措施，（1）教给孩子太阳紫外线对人体的影响；（2）使用阴影避免强烈的晒伤，并实施打滑，打滑，打巴掌。特别重要的是，要学会在儿童时期使用防晒霜的习惯。我想推荐SPF为10至15，PA ++的防晒霜，这种防晒霜对皮肤的刺激性较小，在上幼儿园或学校时不会被皮肤吸收。另外，在夏季长时间暴露于强烈太阳紫外线下的户外运动和休闲活动中，请使用SPF30或更高版本和PA +++，尽情享受自己的生活，而不必担心晒伤。 20岁以后，随着光老化的进行，会添加局部抗氧化剂和补品作为抗氧化剂和消炎剂。当今天的孩子加入老年人行列时，我希望他们以30至40岁的年轻皮肤为社会做出光明和积极的贡献。

Clinical application of new antioxidants (APPS, TPNa) by Dr. Nose (Director of Clinic Nose)

Abstract: APPS (ascorbyl palmitate) is an interesting vitamin C derivative that has significantly improved skin permeability by binding lipids to ascorbic acid phosphate and modifying fatty acids to water-soluble vitamin C. In addition, TPS (Na tocopherol phosphate) is a vitamin E derivative whose permeability is improved by modifying fat-soluble vitamin E with water-soluble phosphoric acid. These antioxidant molecules have a hydrophilic and hydrophobic structure in the molecule. Therefore, it easily passes through the skin barrier layer and also retains an appropriate barrier property against intramolecular lipids. Therefore, it was considered that the property of solving the problem of dryness of conventional APS and the problem of stickiness of VCIP at the same time and having an extremely good feel after application is extremely useful as vitamin C for home care. Although these molecules contain lipids, water-soluble salt solutions can be easily prepared and iontophoresis is possible. We report that this external preparation containing APPS and TPS was applied to multiple cases that seemed to be effective in outpatient dermatology, and some findings were obtained.

摘要：APPS（抗坏血酸棕榈酸酯）是一种有趣的维生素C衍生物，通过将脂质与抗坏血酸磷酸酯结合并将脂肪酸改性为水溶性维生素C，可显着改善皮肤渗透性。另外，TPS（磷酸钠生育酚）是维生素E衍生物，其通过用水溶性磷酸改性脂溶性维生素E而提高了渗透性。这些抗氧化剂分子在分子中具有亲水和疏水结构。因此，它容易穿过皮肤屏障层，并且还保留了对分子内脂质的适当屏障性质。因此，认为同时解决常规APS的干燥问题和VCIP的粘性问题并且在施用后具有极好的感觉的性质作为用于家庭护理的维生素C非常有用。尽管这些分子包含脂质，但是可以容易地制备水溶性盐溶液并且可以进行离子电渗疗法。我们报告说，这种包含APPS和TPS的外部制剂已应用于似乎在门诊皮肤病学方面有效的多个病例，并且获得了一些发现。

‘’Clinical application of medical esthetics’’ by

Dr. Kiyoaki Tsutsumi (Director, Department of Plastic Surgery, Nagai Clinic)

The 49th Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery Luncheon Seminar

Date: April 14, 2006 (Friday)

Chair: Professor Hiroshi Ueishi (Professor, Department of Plastic Surgery, Kinki University School of Medicine)

"Application of novel antioxidant molecules in the field of plastic surgery" by

Dr. Inui, Department of Dermatology, Osaka University

‘’Iontophoresis effect of new antioxidant molecules (APPS, fullerenes, TDMG) using the new skin evaluation device’’ by Dr. Nose

‘’Therapy with new antioxidant molecules (APPS, fullerenes, TDMG)’’ by Dr. Terashima

Japan Society of Obstetrics and Gynecology General Assembly Luncheon Seminar

Date : April 2006

‘’Clinical application of medical esthetic’’ by

Dr. Kiyoaki Tsutsumi (Director, Department of Plastic Surgery, Nagai Clinic)

‘’Clinical application of new antioxidants (APPS, TPNa)’’ by

Professor Terashima (Director of Avenue Omotesando Clinic)

‘’Clinical application of new antioxidants (APPS, TPNa)’’ by

Professor Satoshi Tsuzuki (Showa Denko)

2005

The 104th Annual Meeting of the Japanese Dermatological Association

Date: April 23, 2005 (Saturday) at Pacifico Yokohama

Chair: Professor Akira Kawada, Professor of Dermatology, Kinki University School of Medicine

Theme: New Treatments for Acne "Usefulness of Next Generation Vitamin C Derivatives (APPS) in Dermatology" by Dr. Akamatsu (Department of Dermatology, Fujita Health University)

Abstract: Acne vulgaris is a disease that occurs when various factors are intricately intertwined, so it is often experienced to be resistant to common treatments such as administration of antibiotics and vitamins, and once improved. Even if it looks like it, it recurs easily, and it is often difficult to cure it. We have performed complex treatments for acne vulgaris with antibiotics, retinoic acid, chemical peels, and vitamin C derivatives with very good results. These treatments can treat existing lesions and prevent the development of new lesions by effectively blocking the process of acne vulgaris development and exacerbation in multiple stages. The actual treatment of such complex acne vulgaris and the efficacy of the recently introduced novel vitamin C derivative APPS will be described in detail.

摘要：寻常痤疮是一种在多种因素错综复杂的情况下发生的疾病，因此通常对抗生素和维生素等常见治疗有抵抗力，并且一旦得到改善，即使看起来很容易复发，而且通常很难治愈。我们用抗生素，视黄酸，化学果皮和维生素C衍生物对寻常性痤疮进行了综合治疗，效果非常好。这些治疗方法可以有效地阻止寻常痤疮在多个阶段的发展和恶化，从而可以治疗现有的病变并预防新病变的发展。将详细描述这种复杂的寻常痤疮的实际治疗方法和最近推出的新型维生素C衍生物APPS的功效。

‘’Clinical application of new antioxidants (APPS)’’ by Professor Terashima (Director of Avenue Omotesando Clinic)

‘’Clinical application of new antioxidants (APPS)’’ by Dr. Nose (Director of Clinic Nose)

General Assembly of the Japan Society of Obstetrics and Gynecology

Date: April 3, 2005 (Sunday) at Kyoto International Conference Center

Theme: "Usefulness of cosmetics in ladies' clinics"

"Application of anti-aging cosmetics in obstetrics and gynecology" by

Dr. Kiyoaki Tsutsumi (Director, Department of Plastic Surgery, Nagai Clinic)

"Basic study of new water-soluble vitamin E derivative (γ-TDMG)" by

Professor Jiro Takada, Associate Professor, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University

"Characteristics of high-penetration novel vitamin C derivatives" by

Showa Denko R & D Center, Professor Tadashi Yoneda

"Development of new anti-aging molecule (fullerene)" by

Vitamin C60 Bio Research Co., Ltd., President Kenji Matsubayashi

The 48th Annual Meeting of the Japanese Society of Plastic Surgery

Date: April13, 2005 (Wednesdays) at Sin-Takanawa Prince Hotel

Title: Usefulness of new antioxidant cosmetic ingredients in the field of plastic surgery

Chair: Hiroshi Ueishi, Professor of Plastic Surgery, Kinki University School of Medicine

"Development of new anti-aging molecule (fullerene)" by

Vitamin C60 Bio Research Co., Ltd., President Kenji Matsubayashi

"Characteristics of high-penetration novel vitamin C derivatives" by

Showa Denko R & D Center, Professor Tadashi Yoneda

"Basic study of new water-soluble vitamin E derivative (γ-TDMG)" by Professor Jiro Takada, Associate Professor, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University

2004

The 56th Annual Meeting of the Japanese Society of Obstetrics and Gynecology

Date: April 11, 2004 at Hotel Grand Pacific Meridian

Theme: "Effectiveness of beauty and cosmetics in obstetrics and gynecology"

Chair: Professor Bunpei Ishizuka, Department of Obstetrics and Gynecology, St. Marianna University School of Medicine

"Cosmetology related to health" by Dr. Ryuichi Utsugi, Director, Center for Aesthetic Medicine, Kitasato Institute Hospital

"Examination of the effectiveness of external vitamin C derivatives in the field of obstetrics and gynecology" by Nagai Clinic Obstetrics / Gynecology / Plastic Surgery / Anesthesiology / Neonatology Clinician Kiyoaki Tsutsumi

The 103rd Annual Meeting of the Japanese Dermatological Association

Chair: Professor Akira Kawada, Department of Dermatology, Faculty of Medicine, Kinki University

Date: April 16, 2004

"Manufacturing and sales of cosmetics and the basics of the Pharmaceutical Affairs Law"

"Revision of cosmetic regulations and safety of cosmetic ingredients" by

Hirota Technician Office Chemical Technology Consultant Hirota Hirota

"Attention new cosmetic ingredients" by

Showa Denko Corporation Research Institute Satoshi Tsuzuki

The 47th Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery

Date: April 7 ~ 9, 2004 at Keio Plaza Hotel

Chair: Professor Hiroshi Ueishi, Associate Professor, Department of Plastic Surgery, Kinki University School of Medicine

Date : April 8, 2004

"Revision of cosmetic regulations and safety of cosmetic ingredients, development and clinical application of provitamin C"

"Revision of cosmetic regulations and safety of cosmetic ingredients" by Hirota Technician Office Chemical Technology Consultant Hirota Hirota

"Introduction of whitening cosmetic ingredients" by ABI Corporation Development Department

"Introduction of new cosmetic ingredients" by Shinobu Ito, Director of Vitamin Search, ITO Pro Co., Ltd.

2003

The 46th Annual Meeting of the Japan Society of Plastic and Reconstructive Surgery

Date: April 9 ~ 11, 2003 at Koe Portpier Hotel

April 9, 2003

Chair: Dr. Kitaro Omori, Department of Plastic Surgery, Tokyo Metropolitan Police Hospital

April 8, 2004

"Possibilities of new cosmetic raw materials and laser utilization in the field of plastic surgery"

"Clinical application of provitamin C and cosmetic materials" by

Dr. Yoichi Terashima, Tokyo Metropolitan Police Hospital

"Development of new cosmetic ingredients effective in the field of plastic surgery" by

Showa Denko Co., Ltd. Satoshi Tsuzuki

Others